Hypersensitivity reaction

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Type Mechanism Examples
I immediate IgE-mediated reaction anaphylaxis, allergies, asthma
II antibody-mediated cytotoxic reaction autoimmune hemolytic anemia, pemphigus vulgaris, Goodpasture syndrome, myasthenia gravis, Graves disease
III immune complex-mediated reaction systemic lupus erythematosus, post-streptococcal glomerulonephritis, serum sickness
IV delayed cell-mediated reaction drug reaction with eosinophilia and systemic symptoms, poison ivy, type 1 diabetes mellitus, multiple sclerosis, rheumatoid arthritis, tuberculosis
IVa delayed Th1-mediated reaction
IVb delayed Th2-mediated reaction
IVc delayed CD8 T-cell-mediated reaction
IVd delayed T-cell-mediated neutrophilic reaction