| Immune Defect
|
Typical Infections
|
Typical Organisms
|
| cell-mediated (T cells)
|
persistent viral infections, opportunistic infections, disseminated infections
|
Pneumocystis jirovecii, Cryptococcus, Herpesviridae
|
| humoural (B cells)
|
respiratory infections with encapsulated organisms, chronic diarrhea, aseptic meningitis
|
Haemophilus influenzae, Streptococcus pneumoniae, Giardia lamblia, Campylobacter species, enteroviruses
|
| phagocytic
|
recurrent abscesses, gingivitis, aphthous ulcers
|
Staphylococcus aureus, Burkholderia cepacia, Serratia marcescens, Aspergillus species, Nocardia species
|
| monocytic
|
disseminated infections and multifocal osteomyelitis
|
non-tuberculous mycobacteria, Salmonella species, Histoplasma capsulatum, Coccidioides immitis
|
| TLR
|
recurrent meningitis, bacteremia, absence of fever
|
Streptococcus pneumoniae, Neisseria meningitidis, Staphylococcus aureus, HSV
|
| complement
|
recurrent bacteremia and meningitis
|
Neisseria species
|
| T cells and phagocytes
|
eczema, kyphoscoliosis, pathologic fratures, pulmonary and cutaneous infections, mucocutaneous candidiasis
|
Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Candida albicans
|
