Pharmacokinetics and pharmacodynamics

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Antimicrobial Bactericidal Pattern PK-PD Measure
aminoglycosides concentration-dependent AUC0-24:MIC, Cmax:MIC
β-lactams time-dependent T>MIC
clindamycin time-dependent AUC0-24:MIC
daptomycin concentration-dependent AUC0-24:MIC, Cmax:MIC
vancomycin time-dependent AUC0-24:MIC
azithromycin time-dependent AUC0-24:MIC
clarithromycin time-dependent AUC0-24:MIC
metronidazole concentration-dependent AUC0-24:MIC, Cmax:MIC
linezolid time-dependent AUC0-24:MIC
fluoroquinolones concentration-dependent AUC0-24:MIC, Cmax:MIC
doxycycline time-dependent AUC0-24:MIC
tigecycline time-dependent AUC0-24:MIC

Further Reading

  • Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore. Clin Infect Dis. 2007;44(1):79-86. doi: 10.1086/510079