Pharmacokinetics and pharmacodynamics
From IDWiki
Background
- Pharmacokinetics refers to the movement of drug through the body, and is characterized by absorption, distribution, metabolism, and excretion
- Pharmacodynamics refers to the effect of the drug on the body
Antimicrobials
| Antimicrobial | Bactericidal Pattern | PK-PD Measure |
|---|---|---|
| aminoglycosides | concentration-dependent | AUC0-24:MIC, Cmax:MIC |
| β-lactams | time-dependent | T>MIC |
| clindamycin | time-dependent | AUC0-24:MIC |
| daptomycin | concentration-dependent | AUC0-24:MIC, Cmax:MIC |
| vancomycin | time-dependent | AUC0-24:MIC |
| azithromycin | time-dependent | AUC0-24:MIC |
| clarithromycin | time-dependent | AUC0-24:MIC |
| metronidazole | concentration-dependent | AUC0-24:MIC, Cmax:MIC |
| linezolid | time-dependent | AUC0-24:MIC |
| fluoroquinolones | concentration-dependent | AUC0-24:MIC, Cmax:MIC |
| doxycycline | time-dependent | AUC0-24:MIC |
| tigecycline | time-dependent | AUC0-24:MIC |
Further Reading
- Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore. Clin Infect Dis. 2007;44(1):79-86. doi: 10.1086/510079
