Drug-drug interactions

CYP	Inhibitors		Inducers	Substrates
CYP1A2	amiodarone cimetidine ciprofloxacin	fluvoxamine interferon methoxsalen	cigarette smoking marijuana smoking modafinil nafcillin	amitriptyline caffeine clomipramine clozapine cyclobenzaprine estradiol fluvoxamine haloperidol	mexiletine naproxen olanzapine ondansetron phenacetine propranolol riluzole ropivacaine	tacrine theophylline tizanidine verapamil R-warfarin zileuton zolmitriptan
CYP	Inhibitors		Inducers	Substrates
CYP2B6	ticlopidine	thiotepa	phenobarbital rifampin	bupropion cyclophosphamide	efavirenz ifosfamide	methadone
CYP	Inhibitors		Inducers	Substrates
CYP2C8	gemfibrozil montelukast pioglitazone	quercetin rosiglitazone trimethoprim	rifampin	amodiaquine dasabuvir	cerivastatin paclitaxel	torsemide repaglinide
CYP	Inhibitors		Inducers	Substrates
CYP2C9	amiodarone fenofibrate fluconazole fluvastatin fluvoxamine isoniazid	probenecid sertraline sulfamethoxazole teniposide voriconazole zafirlukast	rifampin secorbarbital	amitriptyline celecoxib diclofenac fluoxetine fluvastatin glipizide glyburide ibuprofen	irbesartan lornoxicam losartan meloxicam nateglinide omeprazole phenytoin	piroxicam rosiglitazone rosuvastatin S-warfarin tamoxifen tolbutamide torsemide
CYP	Inhibitors		Inducers	Substrates
CYP2C19	cimetidine esomeprazole felbamate fluoxetine fluvoxamine indomethacin ketoconazole lansoprazole	modafinil omeprazole oxcarbazepine pantoprazole probenecid rabeprazole ticlopidine topiramate	carbamazepine norethindrone prednisone rifampin	carisoprodol chloramphenicol citalopram clomipramine cyclophosphamide esomeprazole hexobarbital indomethacin	lansoprazole moclobemide nelfinavir nilutamide omeprazole pantoprazole phenobarbital phenytoin	primidone progesterone proguanil propranolol rabeprazole teniposide voriconazole
CYP	Inhibitors		Inducers	Substrates
CYP2D6	amiodarone bupropion celecoxib chlorpheniramine chlorpromazine cimetidine citalopram clemastine clomipramine cocaine diphenhydramine doxepin doxorubicin duloxetine escitalopram	fluoxetine hydroxyzine metoclopramide mibefradil midodrine moclobemide paroxetine perphenazine quinidine ranitidine ritonavir sertraline terbinafine ticlopidine	dexamethasone rifampin	alprenolol amitriptyline amphetamine aripiprazole atomoxetine carvedilol chlorpheniramine chlorpromazine clomipramine codeine	debrisoquine desipramine dexfenfluramine dextromethorphan duloxetine encainide flecainide fluoxetine fluvoxamine haloperidol	imipramine lidocaine methoxyamphetamine metoclopramide paroxetine perphenazine propafenone S-metoprolol thioridazine timolol
CYP	Inhibitors		Inducers	Substrates
CYP2E1	disulfiram		ethanol isoniazid	acetaminophen chlorzoxazone enflurane	ethanol halothane isoflurane	methoxyflurane sevoflurane
CYP	Inhibitors		Inducers	Substrates
CYP3A	amiodarone aprepitant cimetidine clarithromycin cobicistat delavirdine diltiazem elvitegravir erythromycin fluconazole fluvoxamine gestodene imatinib indinavir	isavuconazonium itraconazole ketoconazole mibefradil mifepristone nefazodone nelfinavir norfluoxetine posaconazole ritonavir saquinavir verapamil voriconazole	barbiturates carbamazepine efavirenz glucocorticoids modafinil nevirapine oxcarbazepine phenobarbital phenytoin pioglitazone rifabutin rifampin St. John’s wort	alfentanil alprazolam amlodipine aprepitant aripiprazole artemisinin astemizole atazanavir atorvastatin bedaquiline buspirone cafergot chlorpheniramine cilostazol clarithromycin cocaine cyclosporine daclatasvir dapsone darunavir dexamethasone dextromethorphan diltiazem docetaxel domperidone elbasvir eplerenone	erythromycin estradiol etravirine felodipine fentanyl finasteride fosamprenavir grazoprevir haloperidol hydrocortisone imitanib indinavir irinotecan lidocaine lovastatin maraviroc midazolam nateglinide nelfinavir nifedipine nisoldipine nitrendipine ondansetron paritaprevir pimozide praziquantel	progesterone quetiapine quinidine quinine risperidone ritonavir salmeterol saquinavir sildenafil simeprevir simvastatin sirolimus tacrolimus tadalafil taxol terfenadine testosterone tipranavir trazodone triazolam vardenafil verapamil vincristine zaleplon ziprasidone zolpidem
CYP	Inhibitors		Inducers	Substrates