Neutropenia

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Background

  • Low concentration of circulating neutrophils
ANC Classification
≥1500 Normal
1000-1499 Mild
500-999 Moderate
<500 Severe
0 Agranulocytosis

Etiologies

Congenital

  • Constitutional neutropenia: mild (ANC>1000), chronic
  • Benign ethnic neutropenia: mild (ANC>1000), chronic, usually in patients with Mediterranean or African ancestry
  • Benign familial neutropenia: same as above, but hereditary and not associated with a specific ethnicity
  • Cyclic neutropenia: hereditary, with severe neutropenia on a 21-day cycle since childhood
  • Others: severe congenital neutropenia, Schwachman-Diamond syndrome, Fanconi anemia, dyskeratosis congenita, Chediak-Higash syndrome, myelokathesis, Griscelli syndrome II, and cartilage-hair hypoplasia

Acquired

Further Reading