Carbapenem-resistant Enterobacterales

Management

• First-line includes meropenem-vaborbactam or ceftazidime-avibactam, directed by susceptibility resultsCiteRef:paul2022eu
• For metallo-β-lactamases or extensively resistant bacteria, consider cefiderocol or aztreonam plus ceftazidime-avibactam
• For non-severe infections, consider aminoglycosides, including plazomicin; tigecycline would be second-line, though it can be considered in pneumonia