Drug-drug interactions: Difference between revisions
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|[[fluvoxamine]]<br />'''[[interferon]]'''<br />methoxsalen |
|[[fluvoxamine]]<br />'''[[interferon]]'''<br />methoxsalen |
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|[[Nicotine use disorder|cigarette smoking]]<br />[[Cannabis use disorder|marijuana smoking]]<br />[[modafinil]]<br />'''[[nafcillin]]''' |
|[[Nicotine use disorder|cigarette smoking]]<br />[[Cannabis use disorder|marijuana smoking]]<br />[[modafinil]]<br />'''[[nafcillin]]''' |
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|[[amitriptyline]]<br />[[caffeine]]<br />[[clomipramine]]<br />[[clozapine]]<br />[[cyclobenzaprine]]<br />[[estradiol]]<br />[[fluvoxamine]] |
|[[amitriptyline]]<br />[[caffeine]]<br />[[clomipramine]]<br />[[clozapine]]<br />[[cyclobenzaprine]]<br />[[estradiol]]<br />[[fluvoxamine]]<br />[[haloperidol]] |
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|mexiletine<br />[[naproxen]]<br />[[olanzapine]]<br />[[ondansetron]]<br />phenacetine<br />[[propranolol]]<br />riluzole<br />ropivacaine |
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[[haloperidol]] |
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|mexiletine<br />[[naproxen]]<br />[[olanzapine]] |
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[[ondansetron]] |
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phenacetine<br />[[propranolol]]<br />riluzole |
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ropivacaine |
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|tacrine<br />[[theophylline]]<br />[[tizanidine]]<br />[[verapamil]]<br />R-[[warfarin]]<br />zileuton<br />[[zolmitriptan]] |
|tacrine<br />[[theophylline]]<br />[[tizanidine]]<br />[[verapamil]]<br />R-[[warfarin]]<br />zileuton<br />[[zolmitriptan]] |
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|[[probenecid]]<br />[[sertraline]]<br />'''[[sulfamethoxazole]]'''<br />teniposide<br />'''[[voriconazole]]'''<br />zafirlukast |
|[[probenecid]]<br />[[sertraline]]<br />'''[[sulfamethoxazole]]'''<br />teniposide<br />'''[[voriconazole]]'''<br />zafirlukast |
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|'''[[rifampin]]'''<br />secorbarbital |
|'''[[rifampin]]'''<br />secorbarbital |
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|[[amitriptyline]]<br />[[celecoxib]]<br />[[diclofenac]]<br />[[fluoxetine]]<br />[[fluvastatin]] |
|[[amitriptyline]]<br />[[celecoxib]]<br />[[diclofenac]]<br />[[fluoxetine]]<br />[[fluvastatin]]<br />[[glipizide]]<br />[[glyburide]]<br />[[ibuprofen]]<br />|[[irbesartan]]<br />lornoxicam<br />[[losartan]]<br />[[meloxicam]]<br />nateglinide<br />[[omeprazole]]<br />[[phenytoin]] |
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[[glipizide]]<br />[[glyburide]] |
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[[ibuprofen]] |
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|[[irbesartan]]<br />lornoxicam<br />[[losartan]] |
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[[meloxicam]]<br />nateglinide<br />[[omeprazole]]<br />[[phenytoin]] |
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|piroxicam<br />[[rosiglitazone]]<br />[[rosuvastatin]]<br />S-[[warfarin]]<br />tamoxifen<br />tolbutamide<br />torsemide |
|piroxicam<br />[[rosiglitazone]]<br />[[rosuvastatin]]<br />S-[[warfarin]]<br />tamoxifen<br />tolbutamide<br />torsemide |
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|[[modafinil]]<br />[[omeprazole]]<br />oxcarbazepine<br />[[pantoprazole]]<br />[[probenecid]]<br />[[rabeprazole]]<br />ticlopidine<br />[[topiramate]] |
|[[modafinil]]<br />[[omeprazole]]<br />oxcarbazepine<br />[[pantoprazole]]<br />[[probenecid]]<br />[[rabeprazole]]<br />ticlopidine<br />[[topiramate]] |
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|[[carbamazepine]]<br />norethindrone<br />prednisone<br />'''[[rifampin]]''' |
|[[carbamazepine]]<br />norethindrone<br />prednisone<br />'''[[rifampin]]''' |
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|carisoprodol<br />'''[[chloramphenicol]]'''<br />[[citalopram]]<br />clomipramine<br />cyclophosphamide<br />esomeprazole<br />hexobarbital |
|carisoprodol<br />'''[[chloramphenicol]]'''<br />[[citalopram]]<br />clomipramine<br />cyclophosphamide<br />esomeprazole<br />hexobarbital<br />indomethacin |
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| ⚫ | |||
indomethacin |
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| ⚫ | |||
[[omeprazole]]<br />[[pantoprazole]]<br />[[phenobarbital]] |
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[[phenytoin]] |
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|primidone<br />[[progesterone]]<br />'''[[proguanil]]'''<br />[[propranolol]]<br />[[rabeprazole]]<br />teniposide<br />'''[[voriconazole]]''' |
|primidone<br />[[progesterone]]<br />'''[[proguanil]]'''<br />[[propranolol]]<br />[[rabeprazole]]<br />teniposide<br />'''[[voriconazole]]''' |
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|- |
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|CYP2D6 |
|CYP2D6 |
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|amiodarone<br />bupropion<br />celecoxib<br />chlorpheniramine<br />chlorpromazine<br />cimetidine<br />citalopram<br />clemastine<br />clomipramine<br />cocaine<br />diphenhydramine<br />doxepin<br />doxorubicin<br />duloxetine |
|amiodarone<br />bupropion<br />celecoxib<br />chlorpheniramine<br />chlorpromazine<br />cimetidine<br />citalopram<br />clemastine<br />clomipramine<br />cocaine<br />diphenhydramine<br />doxepin<br />doxorubicin<br />duloxetine<br />escitalopram |
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escitalopram |
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|fluoxetine<br />hydroxyzine<br />metoclopramide<br />mibefradil<br />midodrine<br />moclobemide<br />paroxetine<br />perphenazine<br />quinidine<br />ranitidine<br />'''[[ritonavir]]'''<br />sertraline<br />terbinafine<br />ticlopidine |
|fluoxetine<br />hydroxyzine<br />metoclopramide<br />mibefradil<br />midodrine<br />moclobemide<br />paroxetine<br />perphenazine<br />quinidine<br />ranitidine<br />'''[[ritonavir]]'''<br />sertraline<br />terbinafine<br />ticlopidine |
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|dexamethasone<br />'''[[rifampin]]''' |
|dexamethasone<br />'''[[rifampin]]''' |
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|alprenolol<br />amitriptyline<br />amphetamine<br />aripiprazole<br />atomoxetine<br />carvedilol<br />chlorpheniramine<br />chlorpromazine<br />clomipramine<br />codeine |
|alprenolol<br />amitriptyline<br />amphetamine<br />aripiprazole<br />atomoxetine<br />carvedilol<br />chlorpheniramine<br />chlorpromazine<br />clomipramine<br />codeine |
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| ⚫ | |||
|debrisoquine |
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| ⚫ | |||
encainide |
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flecainide<br />fluoxetine<br />fluvoxamine<br />haloperidol |
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|imipramine<br />lidocaine<br />methoxyamphetamine<br />metoclopramide<br />paroxetine<br />perphenazine<br />propafenone<br />S-metoprolol<br />thioridazine<br />timolol |
|imipramine<br />lidocaine<br />methoxyamphetamine<br />metoclopramide<br />paroxetine<br />perphenazine<br />propafenone<br />S-metoprolol<br />thioridazine<br />timolol |
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|CYP3A |
|CYP3A |
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|amiodarone<br />aprepitant<br />cimetidine<br />'''[[clarithromycin]]'''<br />'''[[cobicistat]]'''<br />'''[[delavirdine]]'''<br />diltiazem<br />'''[[elvitegravir]]'''<br />'''[[erythromycin]]'''<br />'''[[fluconazole]]'''<br />fluvoxamine<br />gestodene<br />imatinib |
|amiodarone<br />aprepitant<br />cimetidine<br />'''[[clarithromycin]]'''<br />'''[[cobicistat]]'''<br />'''[[delavirdine]]'''<br />diltiazem<br />'''[[elvitegravir]]'''<br />'''[[erythromycin]]'''<br />'''[[fluconazole]]'''<br />fluvoxamine<br />gestodene<br />imatinib<br />'''[[indinavir]]''' |
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'''[[indinavir]]''' |
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|'''[[isavuconazonium]]'''<br />'''[[itraconazole]]'''<br />'''[[ketoconazole]]'''<br />mibefradil<br />mifepristone<br />nefazodone<br />'''[[nelfinavir]]'''<br />norfluoxetine<br />'''[[posaconazole]]'''<br />'''[[ritonavir]]'''<br />'''[[saquinavir]]'''<br />verapamil<br />'''[[voriconazole]]''' |
|'''[[isavuconazonium]]'''<br />'''[[itraconazole]]'''<br />'''[[ketoconazole]]'''<br />mibefradil<br />mifepristone<br />nefazodone<br />'''[[nelfinavir]]'''<br />norfluoxetine<br />'''[[posaconazole]]'''<br />'''[[ritonavir]]'''<br />'''[[saquinavir]]'''<br />verapamil<br />'''[[voriconazole]]''' |
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|barbiturates<br />carbamazepine<br />'''[[efavirenz]]'''<br />glucocorticoids<br />modafinil<br />nevirapine<br />oxcarbazepine<br />phenobarbital<br />phenytoin<br />pioglitazone<br />'''[[rifabutin]]'''<br />'''[[rifampin]]'''<br />St. John’s wort |
|barbiturates<br />carbamazepine<br />'''[[efavirenz]]'''<br />glucocorticoids<br />modafinil<br />nevirapine<br />oxcarbazepine<br />phenobarbital<br />phenytoin<br />pioglitazone<br />'''[[rifabutin]]'''<br />'''[[rifampin]]'''<br />St. John’s wort |
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|alfentanil<br />alprazolam<br />amlodipine<br />aprepitant<br />aripiprazole<br />'''[[artemisinin]]'''<br />astemizole<br />'''[[atazanavir]]'''<br />atorvastatin<br />'''[[bedaquiline]]'''<br />buspirone<br />cafergot<br />chlorpheniramine<br />cilostazol<br />'''[[clarithromycin]]'''<br />cocaine<br />cyclosporine<br />'''[[daclatasvir]]'''<br />'''[[dapsone]]'''<br />'''[[darunavir]]'''<br />dexamethasone<br />dextromethorphan<br />diltiazem<br />docetaxel<br />domperidone<br />'''[[elbasvir]]'''<br />eplerenone |
|alfentanil<br />alprazolam<br />amlodipine<br />aprepitant<br />aripiprazole<br />'''[[artemisinin]]'''<br />astemizole<br />'''[[atazanavir]]'''<br />atorvastatin<br />'''[[bedaquiline]]'''<br />buspirone<br />cafergot<br />chlorpheniramine<br />cilostazol<br />'''[[clarithromycin]]'''<br />cocaine<br />cyclosporine<br />'''[[daclatasvir]]'''<br />'''[[dapsone]]'''<br />'''[[darunavir]]'''<br />dexamethasone<br />dextromethorphan<br />diltiazem<br />docetaxel<br />domperidone<br />'''[[elbasvir]]'''<br />eplerenone |
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|'''[[erythromycin]]'''<br />estradiol<br />'''[[etravirine]]'''<br />felodipine<br />fentanyl<br />finasteride<br />'''[[fosamprenavir]]'''<br />'''[[grazoprevir]]'''<br />haloperidol<br />hydrocortisone<br />imitanib<br />'''[[indinavir]]'''<br />irinotecan<br />lidocaine<br />lovastatin<br />'''[[maraviroc]]'''<br />midazolam<br />nateglinide<br />'''[[nelfinavir]]''' |
|'''[[erythromycin]]'''<br />estradiol<br />'''[[etravirine]]'''<br />felodipine<br />fentanyl<br />finasteride<br />'''[[fosamprenavir]]'''<br />'''[[grazoprevir]]'''<br />haloperidol<br />hydrocortisone<br />imitanib<br />'''[[indinavir]]'''<br />irinotecan<br />lidocaine<br />lovastatin<br />'''[[maraviroc]]'''<br />midazolam<br />nateglinide<br />'''[[nelfinavir]]'''<br />nifedipine<br />nisoldipine<br />nitrendipine<br />ondansetron<br />'''[[paritaprevir]]'''<br />pimozide<br />'''[[praziquantel]]''' |
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nifedipine<br />nisoldipine<br />nitrendipine<br />ondansetron<br />'''[[paritaprevir]]'''<br />pimozide<br />'''[[praziquantel]]''' |
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|progesterone<br />quetiapine<br />quinidine<br />'''[[quinine]]'''<br />risperidone<br />'''[[ritonavir]]'''<br />salmeterol<br />'''[[saquinavir]]'''<br />sildenafil<br />'''[[simeprevir]]'''<br />simvastatin<br />sirolimus<br />tacrolimus<br />tadalafil<br />taxol<br />terfenadine<br />testosterone<br />'''[[tipranavir]]'''<br />trazodone<br />triazolam<br />vardenafil<br />verapamil<br />vincristine<br />zaleplon<br />ziprasidone<br />zolpidem |
|progesterone<br />quetiapine<br />quinidine<br />'''[[quinine]]'''<br />risperidone<br />'''[[ritonavir]]'''<br />salmeterol<br />'''[[saquinavir]]'''<br />sildenafil<br />'''[[simeprevir]]'''<br />simvastatin<br />sirolimus<br />tacrolimus<br />tadalafil<br />taxol<br />terfenadine<br />testosterone<br />'''[[tipranavir]]'''<br />trazodone<br />triazolam<br />vardenafil<br />verapamil<br />vincristine<br />zaleplon<br />ziprasidone<br />zolpidem |
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Revision as of 13:25, 19 August 2020
| CYP | Inhibitors | Inducers | Substrates | |||
|---|---|---|---|---|---|---|
| CYP1A2 | amiodarone cimetidine ciprofloxacin |
fluvoxamine interferon methoxsalen |
cigarette smoking marijuana smoking modafinil nafcillin |
amitriptyline caffeine clomipramine clozapine cyclobenzaprine estradiol fluvoxamine haloperidol |
mexiletine naproxen olanzapine ondansetron phenacetine propranolol riluzole ropivacaine |
tacrine theophylline tizanidine verapamil R-warfarin zileuton zolmitriptan |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2B6 | ticlopidine | thiotepa | phenobarbital rifampin |
bupropion cyclophosphamide |
efavirenz ifosfamide |
methadone |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2C8 | gemfibrozil montelukast pioglitazone |
quercetin rosiglitazone trimethoprim |
rifampin | amodiaquine dasabuvir |
cerivastatin paclitaxel |
torsemide repaglinide |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2C9 | amiodarone fenofibrate fluconazole fluvastatin fluvoxamine isoniazid |
probenecid sertraline sulfamethoxazole teniposide voriconazole zafirlukast |
rifampin secorbarbital |
amitriptyline celecoxib diclofenac fluoxetine fluvastatin glipizide glyburide ibuprofen |irbesartan lornoxicam losartan meloxicam nateglinide omeprazole phenytoin |
piroxicam rosiglitazone rosuvastatin S-warfarin tamoxifen tolbutamide torsemide | |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2C19 | cimetidine esomeprazole felbamate fluoxetine fluvoxamine indomethacin ketoconazole lansoprazole |
modafinil omeprazole oxcarbazepine pantoprazole probenecid rabeprazole ticlopidine topiramate |
carbamazepine norethindrone prednisone rifampin |
carisoprodol chloramphenicol citalopram clomipramine cyclophosphamide esomeprazole hexobarbital indomethacin |
lansoprazole moclobemide nelfinavir nilutamide omeprazole pantoprazole phenobarbital phenytoin |
primidone progesterone proguanil propranolol rabeprazole teniposide voriconazole |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2D6 | amiodarone bupropion celecoxib chlorpheniramine chlorpromazine cimetidine citalopram clemastine clomipramine cocaine diphenhydramine doxepin doxorubicin duloxetine escitalopram |
fluoxetine hydroxyzine metoclopramide mibefradil midodrine moclobemide paroxetine perphenazine quinidine ranitidine ritonavir sertraline terbinafine ticlopidine |
dexamethasone rifampin |
alprenolol amitriptyline amphetamine aripiprazole atomoxetine carvedilol chlorpheniramine chlorpromazine clomipramine codeine |
debrisoquine desipramine dexfenfluramine dextromethorphan duloxetine encainide flecainide fluoxetine fluvoxamine haloperidol |
imipramine lidocaine methoxyamphetamine metoclopramide paroxetine perphenazine propafenone S-metoprolol thioridazine timolol |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2E1 | disulfiram | ethanol isoniazid |
acetaminophen chlorzoxazone enflurane |
ethanol halothane isoflurane |
methoxyflurane sevoflurane | |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP3A | amiodarone aprepitant cimetidine clarithromycin cobicistat delavirdine diltiazem elvitegravir erythromycin fluconazole fluvoxamine gestodene imatinib indinavir |
isavuconazonium itraconazole ketoconazole mibefradil mifepristone nefazodone nelfinavir norfluoxetine posaconazole ritonavir saquinavir verapamil voriconazole |
barbiturates carbamazepine efavirenz glucocorticoids modafinil nevirapine oxcarbazepine phenobarbital phenytoin pioglitazone rifabutin rifampin St. John’s wort |
alfentanil alprazolam amlodipine aprepitant aripiprazole artemisinin astemizole atazanavir atorvastatin bedaquiline buspirone cafergot chlorpheniramine cilostazol clarithromycin cocaine cyclosporine daclatasvir dapsone darunavir dexamethasone dextromethorphan diltiazem docetaxel domperidone elbasvir eplerenone |
erythromycin estradiol etravirine felodipine fentanyl finasteride fosamprenavir grazoprevir haloperidol hydrocortisone imitanib indinavir irinotecan lidocaine lovastatin maraviroc midazolam nateglinide nelfinavir nifedipine nisoldipine nitrendipine ondansetron paritaprevir pimozide praziquantel |
progesterone quetiapine quinidine quinine risperidone ritonavir salmeterol saquinavir sildenafil simeprevir simvastatin sirolimus tacrolimus tadalafil taxol terfenadine testosterone tipranavir trazodone triazolam vardenafil verapamil vincristine zaleplon ziprasidone zolpidem |
| CYP | Inhibitors | Inducers | Substrates | |||
