Mycobacterium leprae: Difference between revisions
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Mycobacterium leprae
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Created page with " == Clinical Presentation == * Incubation period of 3-5 years (with wide range) * Classic presentation is anaesthetic hypopigmented skin lesion with thickened nerves * Clinica..." |
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* Classic presentation is anaesthetic hypopigmented skin lesion with thickened nerves |
* Classic presentation is anaesthetic hypopigmented skin lesion with thickened nerves |
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* Clinical spectrum from tuberculoid, paucibacillary disease to lepromatous, multibacillary disease |
* Clinical spectrum from tuberculoid, paucibacillary disease to lepromatous, multibacillary disease |
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** '''Paucibacillary (PB)''' disease has 1 to 5 skin lesions, without bacilli on skin slit smear |
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** '''Multibacillary (MB)''' disease has more than 5 skin lesions, with or without nerve involvement or bacilli on slit-skin smear (regardless of number of lesions) |
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== Management == |
== Management == |
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Revision as of 03:11, 27 November 2019
Clinical Presentation
- Incubation period of 3-5 years (with wide range)
- Classic presentation is anaesthetic hypopigmented skin lesion with thickened nerves
- Clinical spectrum from tuberculoid, paucibacillary disease to lepromatous, multibacillary disease
- Paucibacillary (PB) disease has 1 to 5 skin lesions, without bacilli on skin slit smear
- Multibacillary (MB) disease has more than 5 skin lesions, with or without nerve involvement or bacilli on slit-skin smear (regardless of number of lesions)
Management
| Disease | Treatment |
|---|---|
| Paucibacillary | 6 months of rifampin, dapsone, and clofazimine |
| Multibacillary | 12 months of rifampin, dapsone, and clofazimine |
| Rifampin resistance | 6 months of at least two second-line drugs with clofazimine, followed by 18 months of one second-line drug with clofazimine |
| Quinolone resistance | As for rifampin resistance, but without a fluoroquinolone |
Second-line antibiotics
References
- ^ Carl Boodman, Jay Keystone, Isaac I. Bogoch. Leprosy chemoprophylaxis of household contacts: A survey of Canadian infectious disease and tropical medicine specialists. Official Journal of the Association of Medical Microbiology and Infectious Disease Canada. 2021. doi:10.3138/jammi-2021-0017.
