Antifungal spectrum of activity: Difference between revisions

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{| class="wikitable"
{| class="wikitable"
! Organism
! Organism
!align="center"| AmB
!align="center"| [[Amphotericin B|AmB]]
!align="center"| Fluc
!align="center"| [[Fluconazole|Fluc]]
!align="center"| Itra
!align="center"| [[Itraconazole|Itra]]
!align="center"| Vori
!align="center"| [[Voriconazole|Vori]]
!align="center"| Posa
!align="center"| [[Posaconazole|Posa]]
!align="center"| Anidula
!align="center"| [[Anidulafungin|Anidula]]
!align="center"| Caspo
!align="center"| [[Caspofungin|Caspo]]
!align="center"| Mica
!align="center"| [[Micafungin|Mica]]
!align="center"| Flucyt
!align="center"| [[Flucytasine|Flucyt]]
|-
|-
| ''Aspergillus'' spp.
| [[Aspergillus species]]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
|  ''A. flavus''
|  [[Aspergillus flavus|''A. flavus'']]
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
|  ''A. fumigatus''
|  [[Aspergillus fumigatus|''A. fumigatus'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
|  ''A. terreus''
|  [[Aspergillus terreus|''A. terreus'']]
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
|  ''A. niger''
|  [[Aspergillus niger|''A. niger'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| ''Candida'' spp.
| [[Candida species]]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. albicans''
|  [[Candida albicans|''C. albicans'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. glabrata''
|  [[Candida glabrata|''C. glabrata'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. krusei''
|  [[Candida krusei|''C. krusei'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|-
|-
|  ''C. lusitaniae''
|  [[Candida lusitaniae|''C. lusitaniae'']]
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. parapsilosis''
|  [[Candida parapsilosis|''C. parapsilosis'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. tropicalis''
|  [[Candida tropicalis|''C. tropicalis'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
| ''Cryptococcus neoformans''
| [[Cryptococcus neoformans]]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
| ''Coccidioides'' spp.
| [[Coccidioides imitis|''Coccidioides'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| ''Blastomyces''
| [[Blastomyces dermatitidis|''Blastomyces'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| ''Histoplasma'' spp.
| [[Histoplasma capsulatum|''Histoplasma'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| ''Fusarium'' spp.
| [[Fusarium species]]
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| ''Scedosporium apiospermum''
| ''[[Scedosporium apiospermum]]''
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| ''Scedosporium prolificans''
| ''[[Scedosporium prolificans]]''
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|-
|-
| Zygomycetes
| [[Zygomycetes]]
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" | ±
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|align="center"| –
| style="text-align:center;background-color:indianred" | –
|}
|}



Revision as of 00:41, 15 October 2019

Organism AmB Fluc Itra Vori Posa Anidula Caspo Mica Flucyt
Aspergillus species + + + + + + +
A. flavus ± + + + + + +
A. fumigatus + + + + + + +
A. terreus + + + + + +
A. niger + ± + + + + +
Candida species + + + + + + + + +
C. albicans + + + + + + + + +
C. glabrata + ± ± + + + + + +
C. krusei + ± + + + + + ±
C. lusitaniae + + + + + + + +
C. parapsilosis + + + + + ± ± ± +
C. tropicalis + + + + + + + + +
Cryptococcus neoformans + + + + + +
Coccidioides + + + + + ± ± ±
Blastomyces + + + + + ± ± ±
Histoplasma + + + + + ± ± ±
Fusarium species ± + +
Scedosporium apiospermum ± ± + +
Scedosporium prolificans ± ±
Zygomycetes ± +

Aspergillus ustus is resistant to azoles and echinocandins, and variable resistance to amphotericin (though still susceptible to terbinafine)

Source: Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492