Rash involving palms and soles

• Infectious
  • Syphilis
  • Rocky Mountain spotted fever
  • Rat-bite fever
  • Infective endocarditis
  • Ehrlichiosis
  • Toxic shock syndrome
  • Murine typhus
  • Measles
  • Hand-foot-mouth disease
  • Scabies
  • Chikungunya
  • Monkeypox (and smallpox)
  • Parvovirus B19 papular-pustular glove and socks syndrome (PPGSS)
• Non-infectious
  • DRESS syndrome
  • Kawasaki disease
  • Cutaneous T-cell lymphoma
  • Mastocytosis
  • Palmoplantar keratoderma
  • Erythromelalgia
  • Cowden disease
  • Adult-onset Still disease
  • Acute cutaneous lupus erythematosus
  • SAPHO syndrome
  • Reactive arthritis