Local replication in the GI tract followed by viremia that seeds to other sites including upper respiratory tract (including conjunctivae) and meninges
Some are transmitted via droplet/contact via eyes, especially some of the exclusively respiratory viruses like EV-D68
There is receptor tropism by genotype
Epidemiology
Most common cause of aseptic meningitis
Risk Factors
Hypogammaglobulinemia from a number of causes
Neonates
Clinical Manifestations
Clinical syndromes are myriad, including mild febrile illnesses, upper or lower respiratory infections, aseptic meningitis, encephalitis, paralysis, myocarditis, and neonatal enteroviral sepsis
Hand-Foot-Mouth Disease
Typically caused by group A enteroviruses, especially coxsackie A16, enterovirus A71, and enterovirus A6
Causes painful lesions in oral mucosa and palms and soles in young children