Multidrug-resistant organism: Difference between revisions
From IDWiki
No edit summary |
(→) |
||
| Line 3: | Line 3: | ||
* Microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents |
* Microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents |
||
* Definition varies from hospital to hospital or country to country |
* Definition varies from hospital to hospital or country to country |
||
* Generally includes the following bacteria: |
|||
** Gram-positives |
|||
*** [[MRSA]] |
|||
*** [[VRE]] |
|||
*** Multidrug-resistant [[Streptococcus pneumoniae]] |
|||
** Gram-negatives: |
|||
*** [[ESBL]] and CPE |
|||
*** [[Acinetobacter baumannii complex]] |
|||
*** [[Stenotrophomonas maltophilia]] |
|||
*** [[Burkholderia cepacia]] |
|||
*** [[Ralstonia pickettii]] |
|||
=== European CDC Definitions === |
=== European CDC Definitions === |
||
Revision as of 21:10, 2 October 2022
Background
- Microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents
- Definition varies from hospital to hospital or country to country
European CDC Definitions
- Defined by the European CDC[1] as non-susceptibility to at least one agent in three or more categories of antimicrobials, with the categories varying by organism
- Multidrug resistant (MDR) is non-susceptible to at least 1 agent in at least 3 categories
- For Staphylococcus aureus, it automatically includes MRSA, but requires resistance in >3 categories
- Extensively drug-resistant (XDR) is non-susceptible to at least 1 agent in all but 2 categories
- Pan-drug resistant (PDR) is non-susceptible to all listed agents
- For species with intrinsic resistance to a category or agent, it should be excluded before counting
- ↑ Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012 Mar;18(3):268-81. doi: 10.1111/j.1469-0691.2011.03570.x. Epub 2011 Jul 27. PMID: 21793988.
