Drug-drug interactions: Difference between revisions
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(Created page with "{| class="wikitable" ! CYP ! Inhibitors ! Inducers ! Substrates |- | CYP1A2 | amiodarone<br/>cimetidine<br/>'''ciprofloxacin'''<br/>fluvoxamine<br/>'''interferon'''<br...") |
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{| class="wikitable" |
{| class="wikitable" |
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! |
!CYP |
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! Inhibitors |
! colspan="2" |Inhibitors |
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! |
!Inducers |
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! Substrates |
! colspan="3" |Substrates |
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|- |
|- |
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| |
|CYP1A2 |
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| |
|[[amiodarone]]<br />[[cimetidine]]<br />'''[[ciprofloxacin]]''' |
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|[[fluvoxamine]]<br />'''[[interferon]]'''<br />methoxsalen |
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| cigarette smoking<br/>marijuana smoking<br/>modafinil<br/>'''[[nafcillin]]''' |
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|[[Nicotine use disorder|cigarette smoking]]<br />[[Cannabis use disorder|marijuana smoking]]<br />[[modafinil]]<br />'''[[nafcillin]]''' |
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| amitriptyline<br/>caffeine<br/>clomipramine<br/>clozapine<br/>cyclobenzaprine<br/>estradiol<br/>fluvoxamine<br/>haloperidol<br/>mexiletine<br/>naproxen<br/>olanzapine<br/>ondansetron<br/>phenacetine<br/>propranolol<br/>riluzole<br/>ropivacaine<br/>tacrine<br/>theophylline<br/>tizanidine<br/>verapamil<br/>R-warfarin<br/>zileuton<br/>zolmitriptan |
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|[[amitriptyline]]<br />[[caffeine]]<br />[[clomipramine]]<br />[[clozapine]]<br />[[cyclobenzaprine]]<br />[[estradiol]]<br />[[fluvoxamine]] |
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[[haloperidol]] |
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|mexiletine<br />[[naproxen]]<br />[[olanzapine]] |
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[[ondansetron]] |
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phenacetine<br />[[propranolol]]<br />riluzole |
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ropivacaine |
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|tacrine<br />[[theophylline]]<br />[[tizanidine]]<br />[[verapamil]]<br />R-[[warfarin]]<br />zileuton<br />[[zolmitriptan]] |
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|- |
|- |
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!CYP |
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| CYP2B6 |
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! colspan="2" |Inhibitors |
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| ticlopidine<br/>thiotepa |
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!Inducers |
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| phenobarbital<br/>'''[[rifampin]]''' |
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! colspan="3" |Substrates |
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| bupropion<br/>cyclophosphamide<br/>'''[[efavirenz]]'''<br/>ifosfamide<br/>methadone |
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|- |
|- |
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|CYP2B6 |
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| CYP2C8 |
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|ticlopidine |
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| gemfibrozil<br/>montelukast<br/>pioglitazone<br/>quercetin<br/>rosiglitazone<br/>'''[[trimethoprim]]''' |
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|thiotepa |
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| '''[[rifampin]]''' |
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|[[phenobarbital]]<br />'''[[rifampin]]''' |
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| amodiaquine<br/>'''[[dasabuvir]]'''<br/>cerivastatin<br/>paclitaxel<br/>torsemide<br/>repaglinide |
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|[[bupropion]]<br />[[cyclophosphamide]] |
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|'''[[efavirenz]]'''<br />[[ifosfamide]] |
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|[[methadone]] |
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|- |
|- |
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!CYP |
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| CYP2C9 |
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! colspan="2" |Inhibitors |
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| amiodarone<br/>fenofibrate<br/>'''[[fluconazole]]'''<br/>fluvastatin<br/>fluvoxamine<br/>'''[[isoniazid]]'''<br/>probenecid<br/>sertraline<br/>'''[[sulfamethoxazole]]'''<br/>teniposide<br/>'''[[voriconazole]]'''<br/>zafirlukast |
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!Inducers |
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| '''[[rifampin]]'''<br/>secorbarbital |
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! colspan="3" |Substrates |
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| amitriptyline<br/>celecoxib<br/>diclofenac<br/>fluoxetine<br/>fluvastatin<br/>glipizide<br/>glyburide<br/>ibuprofen<br/>irbesartan<br/>lornoxicam<br/>losartan<br/>meloxicam<br/>nateglinide<br/>omeprazole<br/>phenytoin<br/>piroxicam<br/>rosiglitazone<br/>rosuvastatin<br/>S-warfarin<br/>tamoxifen<br/>tolbutamide<br/>torsemide |
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|- |
|- |
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|CYP2C8 |
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| CYP2C19 |
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|[[gemfibrozil]]<br />[[montelukast]]<br />[[pioglitazone]] |
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| cimetidine<br/>esomeprazole<br/>felbamate<br/>fluoxetine<br/>fluvoxamine<br/>indomethacin<br/>'''[[ketoconazole]]'''<br/>lansoprazole<br/>modafinil<br/>omeprazole<br/>oxcarbazepine<br/>pantoprazole<br/>probenecid<br/>rabeprazole<br/>ticlopidine<br/>topiramate |
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| |
|quercetin<br />[[rosiglitazone]]<br />'''[[trimethoprim]]''' |
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|'''[[rifampin]]''' |
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| carisoprodol<br/>'''[[chloramphenicol]]'''<br/>citalopram<br/>clomipramine<br/>cyclophosphamide<br/>esomeprazole<br/>hexobarbital<br/>indomethacin<br/>lansoprazole<br/>moclobemide<br/>'''[[nelfinavir]]'''<br/>nilutamide<br/>omeprazole<br/>pantoprazole<br/>phenobarbital<br/>phenytoin<br/>primidone<br/>progesterone<br/>'''[[proguanil]]'''<br/>propranolol<br/>rabeprazole<br/>teniposide<br/>'''[[voriconazole]]''' |
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|amodiaquine<br />'''[[dasabuvir]]''' |
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|cerivastatin<br />[[paclitaxel]] |
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|torsemide<br />[[repaglinide]] |
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|- |
|- |
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!CYP |
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| CYP2D6 |
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! colspan="2" |Inhibitors |
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| amiodarone<br/>bupropion<br/>celecoxib<br/>chlorpheniramine<br/>chlorpromazine<br/>cimetidine<br/>citalopram<br/>clemastine<br/>clomipramine<br/>cocaine<br/>diphenhydramine<br/>doxepin<br/>doxorubicin<br/>duloxetine<br/>escitalopram<br/>fluoxetine<br/>hydroxyzine<br/>metoclopramide<br/>mibefradil<br/>midodrine<br/>moclobemide<br/>paroxetine<br/>perphenazine<br/>quinidine<br/>ranitidine<br/>'''[[ritonavir]]'''<br/>sertraline<br/>terbinafine<br/>ticlopidine |
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!Inducers |
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| dexamethasone<br/>'''[[rifampin]]''' |
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! colspan="3" |Substrates |
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| alprenolol<br/>amitriptyline<br/>amphetamine<br/>aripiprazole<br/>atomoxetine<br/>carvedilol<br/>chlorpheniramine<br/>chlorpromazine<br/>clomipramine<br/>codeine<br/>debrisoquine<br/>desipramine<br/>dexfenfluramine<br/>dextromethorphan<br/>duloxetine<br/>encainide<br/>flecainide<br/>fluoxetine<br/>fluvoxamine<br/>haloperidol<br/>imipramine<br/>lidocaine<br/>methoxyamphetamine<br/>metoclopramide<br/>paroxetine<br/>perphenazine<br/>propafenone<br/>S-metoprolol<br/>thioridazine<br/>timolol |
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|- |
|- |
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|CYP2C9 |
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| CYP2E1 |
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|[[amiodarone]]<br />[[fenofibrate]]<br />'''[[fluconazole]]'''<br />[[fluvastatin]]<br />[[fluvoxamine]]<br />'''[[isoniazid]]''' |
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| disulfiram |
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|[[probenecid]]<br />[[sertraline]]<br />'''[[sulfamethoxazole]]'''<br />teniposide<br />'''[[voriconazole]]'''<br />zafirlukast |
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| ethanol<br/>'''[[isoniazid]]''' |
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|'''[[rifampin]]'''<br />secorbarbital |
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| acetaminophen<br/>chlorzoxazone<br/>enflurane<br/>ethanol<br/>halothane<br/>isoflurane<br/>methoxyflurane<br/>sevoflurane |
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|[[amitriptyline]]<br />[[celecoxib]]<br />[[diclofenac]]<br />[[fluoxetine]]<br />[[fluvastatin]] |
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[[glipizide]]<br />[[glyburide]] |
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[[ibuprofen]] |
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|[[irbesartan]]<br />lornoxicam<br />[[losartan]] |
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[[meloxicam]]<br />nateglinide<br />[[omeprazole]]<br />[[phenytoin]] |
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|piroxicam<br />[[rosiglitazone]]<br />[[rosuvastatin]]<br />S-[[warfarin]]<br />tamoxifen<br />tolbutamide<br />torsemide |
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|- |
|- |
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!CYP |
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| CYP3A |
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! colspan="2" |Inhibitors |
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| amiodarone<br/>aprepitant<br/>cimetidine<br/>'''[[clarithromycin]]'''<br/>'''[[cobicistat]]'''<br/>'''[[delavirdine]]'''<br/>diltiazem<br/>'''[[elvitegravir]]'''<br/>'''[[erythromycin]]'''<br/>'''[[fluconazole]]'''<br/>fluvoxamine<br/>gestodene<br/>imatinib<br/>'''[[indinavir]]'''<br/>'''[[isavuconazonium]]'''<br/>'''[[itraconazole]]'''<br/>'''[[ketoconazole]]'''<br/>mibefradil<br/>mifepristone<br/>nefazodone<br/>'''[[nelfinavir]]'''<br/>norfluoxetine<br/>'''[[posaconazole]]'''<br/>'''[[ritonavir]]'''<br/>'''[[saquinavir]]'''<br/>verapamil<br/>'''[[voriconazole]]''' |
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!Inducers |
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| barbiturates<br/>carbamazepine<br/>'''[[efavirenz]]'''<br/>glucocorticoids<br/>modafinil<br/>nevirapine<br/>oxcarbazepine<br/>phenobarbital<br/>phenytoin<br/>pioglitazone<br/>'''[[rifabutin]]'''<br/>'''[[rifampin]]'''<br/>St. John’s wort |
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! colspan="3" |Substrates |
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| alfentanil<br/>alprazolam<br/>amlodipine<br/>aprepitant<br/>aripiprazole<br/>'''[[artemisinin]]'''<br/>astemizole<br/>'''[[atazanavir]]'''<br/>atorvastatin<br/>'''[[bedaquiline]]'''<br/>buspirone<br/>cafergot<br/>chlorpheniramine<br/>cilostazol<br/>'''[[clarithromycin]]'''<br/>cocaine<br/>cyclosporine<br/>'''[[daclatasvir]]'''<br/>'''[[dapsone]]'''<br/>'''[[darunavir]]'''<br/>dexamethasone<br/>dextromethorphan<br/>diltiazem<br/>docetaxel<br/>domperidone<br/>'''[[elbasvir]]'''<br/>eplerenone<br/>'''[[erythromycin]]'''<br/>estradiol<br/>'''[[etravirine]]'''<br/>felodipine<br/>fentanyl<br/>finasteride<br/>'''[[fosamprenavir]]'''<br/>'''[[grazoprevir]]'''<br/>haloperidol<br/>hydrocortisone<br/>imitanib<br/>'''[[indinavir]]'''<br/>irinotecan<br/>lidocaine<br/>lovastatin<br/>'''[[maraviroc]]'''<br/>midazolam<br/>nateglinide<br/>'''[[nelfinavir]]'''<br/>nifedipine<br/>nisoldipine<br/>nitrendipine<br/>ondansetron<br/>'''[[paritaprevir]]'''<br/>pimozide<br/>'''[[praziquantel]]'''<br/>progesterone<br/>quetiapine<br/>quinidine<br/>'''[[quinine]]'''<br/>risperidone<br/>'''[[ritonavir]]'''<br/>salmeterol<br/>'''[[saquinavir]]'''<br/>sildenafil<br/>'''[[simeprevir]]'''<br/>simvastatin<br/>sirolimus<br/>tacrolimus<br/>tadalafil<br/>taxol<br/>terfenadine<br/>testosterone<br/>'''[[tipranavir]]'''<br/>trazodone<br/>triazolam<br/>vardenafil<br/>verapamil<br/>vincristine<br/>zaleplon<br/>ziprasidone<br/>zolpidem |
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| |
|- |
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|CYP2C19 |
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|[[cimetidine]]<br />[[esomeprazole]]<br />felbamate<br />[[fluoxetine]]<br />fluvoxamine<br />[[indomethacin]]<br />'''[[ketoconazole]]'''<br />[[lansoprazole]] |
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|[[modafinil]]<br />[[omeprazole]]<br />oxcarbazepine<br />[[pantoprazole]]<br />[[probenecid]]<br />[[rabeprazole]]<br />ticlopidine<br />[[topiramate]] |
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|[[carbamazepine]]<br />norethindrone<br />prednisone<br />'''[[rifampin]]''' |
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|carisoprodol<br />'''[[chloramphenicol]]'''<br />[[citalopram]]<br />clomipramine<br />cyclophosphamide<br />esomeprazole<br />hexobarbital |
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indomethacin |
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|[[lansoprazole]]<br />moclobemide<br />'''[[nelfinavir]]'''<br />nilutamide |
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[[omeprazole]]<br />[[pantoprazole]]<br />[[phenobarbital]] |
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[[phenytoin]] |
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|primidone<br />[[progesterone]]<br />'''[[proguanil]]'''<br />[[propranolol]]<br />[[rabeprazole]]<br />teniposide<br />'''[[voriconazole]]''' |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|- |
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|CYP2D6 |
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|amiodarone<br />bupropion<br />celecoxib<br />chlorpheniramine<br />chlorpromazine<br />cimetidine<br />citalopram<br />clemastine<br />clomipramine<br />cocaine<br />diphenhydramine<br />doxepin<br />doxorubicin<br />duloxetine |
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escitalopram |
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|fluoxetine<br />hydroxyzine<br />metoclopramide<br />mibefradil<br />midodrine<br />moclobemide<br />paroxetine<br />perphenazine<br />quinidine<br />ranitidine<br />'''[[ritonavir]]'''<br />sertraline<br />terbinafine<br />ticlopidine |
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|dexamethasone<br />'''[[rifampin]]''' |
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|alprenolol<br />amitriptyline<br />amphetamine<br />aripiprazole<br />atomoxetine<br />carvedilol<br />chlorpheniramine<br />chlorpromazine<br />clomipramine<br />codeine |
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|debrisoquine |
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desipramine<br />dexfenfluramine<br />dextromethorphan<br />duloxetine |
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encainide |
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flecainide<br />fluoxetine<br />fluvoxamine<br />haloperidol |
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|imipramine<br />lidocaine<br />methoxyamphetamine<br />metoclopramide<br />paroxetine<br />perphenazine<br />propafenone<br />S-metoprolol<br />thioridazine<br />timolol |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|- |
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|CYP2E1 |
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| colspan="2" |disulfiram |
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|ethanol<br />'''[[isoniazid]]''' |
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|acetaminophen<br />chlorzoxazone<br />enflurane |
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|ethanol<br />halothane<br />isoflurane |
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|methoxyflurane<br />sevoflurane |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|- |
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|CYP3A |
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|amiodarone<br />aprepitant<br />cimetidine<br />'''[[clarithromycin]]'''<br />'''[[cobicistat]]'''<br />'''[[delavirdine]]'''<br />diltiazem<br />'''[[elvitegravir]]'''<br />'''[[erythromycin]]'''<br />'''[[fluconazole]]'''<br />fluvoxamine<br />gestodene<br />imatinib |
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'''[[indinavir]]''' |
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|'''[[isavuconazonium]]'''<br />'''[[itraconazole]]'''<br />'''[[ketoconazole]]'''<br />mibefradil<br />mifepristone<br />nefazodone<br />'''[[nelfinavir]]'''<br />norfluoxetine<br />'''[[posaconazole]]'''<br />'''[[ritonavir]]'''<br />'''[[saquinavir]]'''<br />verapamil<br />'''[[voriconazole]]''' |
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|barbiturates<br />carbamazepine<br />'''[[efavirenz]]'''<br />glucocorticoids<br />modafinil<br />nevirapine<br />oxcarbazepine<br />phenobarbital<br />phenytoin<br />pioglitazone<br />'''[[rifabutin]]'''<br />'''[[rifampin]]'''<br />St. John’s wort |
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|alfentanil<br />alprazolam<br />amlodipine<br />aprepitant<br />aripiprazole<br />'''[[artemisinin]]'''<br />astemizole<br />'''[[atazanavir]]'''<br />atorvastatin<br />'''[[bedaquiline]]'''<br />buspirone<br />cafergot<br />chlorpheniramine<br />cilostazol<br />'''[[clarithromycin]]'''<br />cocaine<br />cyclosporine<br />'''[[daclatasvir]]'''<br />'''[[dapsone]]'''<br />'''[[darunavir]]'''<br />dexamethasone<br />dextromethorphan<br />diltiazem<br />docetaxel<br />domperidone<br />'''[[elbasvir]]'''<br />eplerenone |
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|'''[[erythromycin]]'''<br />estradiol<br />'''[[etravirine]]'''<br />felodipine<br />fentanyl<br />finasteride<br />'''[[fosamprenavir]]'''<br />'''[[grazoprevir]]'''<br />haloperidol<br />hydrocortisone<br />imitanib<br />'''[[indinavir]]'''<br />irinotecan<br />lidocaine<br />lovastatin<br />'''[[maraviroc]]'''<br />midazolam<br />nateglinide<br />'''[[nelfinavir]]''' |
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nifedipine<br />nisoldipine<br />nitrendipine<br />ondansetron<br />'''[[paritaprevir]]'''<br />pimozide<br />'''[[praziquantel]]''' |
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|progesterone<br />quetiapine<br />quinidine<br />'''[[quinine]]'''<br />risperidone<br />'''[[ritonavir]]'''<br />salmeterol<br />'''[[saquinavir]]'''<br />sildenafil<br />'''[[simeprevir]]'''<br />simvastatin<br />sirolimus<br />tacrolimus<br />tadalafil<br />taxol<br />terfenadine<br />testosterone<br />'''[[tipranavir]]'''<br />trazodone<br />triazolam<br />vardenafil<br />verapamil<br />vincristine<br />zaleplon<br />ziprasidone<br />zolpidem |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|} |
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[[Category:Antimicrobials]] |
[[Category:Antimicrobials]] |
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Revision as of 13:22, 19 August 2020
| CYP | Inhibitors | Inducers | Substrates | |||
|---|---|---|---|---|---|---|
| CYP1A2 | amiodarone cimetidine ciprofloxacin |
fluvoxamine interferon methoxsalen |
cigarette smoking marijuana smoking modafinil nafcillin |
amitriptyline caffeine clomipramine clozapine cyclobenzaprine estradiol fluvoxamine |
mexiletine naproxen olanzapine phenacetine ropivacaine |
tacrine theophylline tizanidine verapamil R-warfarin zileuton zolmitriptan |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2B6 | ticlopidine | thiotepa | phenobarbital rifampin |
bupropion cyclophosphamide |
efavirenz ifosfamide |
methadone |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2C8 | gemfibrozil montelukast pioglitazone |
quercetin rosiglitazone trimethoprim |
rifampin | amodiaquine dasabuvir |
cerivastatin paclitaxel |
torsemide repaglinide |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2C9 | amiodarone fenofibrate fluconazole fluvastatin fluvoxamine isoniazid |
probenecid sertraline sulfamethoxazole teniposide voriconazole zafirlukast |
rifampin secorbarbital |
amitriptyline celecoxib diclofenac fluoxetine fluvastatin |
irbesartan lornoxicam losartan meloxicam |
piroxicam rosiglitazone rosuvastatin S-warfarin tamoxifen tolbutamide torsemide |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2C19 | cimetidine esomeprazole felbamate fluoxetine fluvoxamine indomethacin ketoconazole lansoprazole |
modafinil omeprazole oxcarbazepine pantoprazole probenecid rabeprazole ticlopidine topiramate |
carbamazepine norethindrone prednisone rifampin |
carisoprodol chloramphenicol citalopram clomipramine cyclophosphamide esomeprazole hexobarbital indomethacin |
lansoprazole moclobemide nelfinavir nilutamide |
primidone progesterone proguanil propranolol rabeprazole teniposide voriconazole |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2D6 | amiodarone bupropion celecoxib chlorpheniramine chlorpromazine cimetidine citalopram clemastine clomipramine cocaine diphenhydramine doxepin doxorubicin duloxetine escitalopram |
fluoxetine hydroxyzine metoclopramide mibefradil midodrine moclobemide paroxetine perphenazine quinidine ranitidine ritonavir sertraline terbinafine ticlopidine |
dexamethasone rifampin |
alprenolol amitriptyline amphetamine aripiprazole atomoxetine carvedilol chlorpheniramine chlorpromazine clomipramine codeine |
debrisoquine
desipramine encainide flecainide |
imipramine lidocaine methoxyamphetamine metoclopramide paroxetine perphenazine propafenone S-metoprolol thioridazine timolol |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP2E1 | disulfiram | ethanol isoniazid |
acetaminophen chlorzoxazone enflurane |
ethanol halothane isoflurane |
methoxyflurane sevoflurane | |
| CYP | Inhibitors | Inducers | Substrates | |||
| CYP3A | amiodarone aprepitant cimetidine clarithromycin cobicistat delavirdine diltiazem elvitegravir erythromycin fluconazole fluvoxamine gestodene imatinib |
isavuconazonium itraconazole ketoconazole mibefradil mifepristone nefazodone nelfinavir norfluoxetine posaconazole ritonavir saquinavir verapamil voriconazole |
barbiturates carbamazepine efavirenz glucocorticoids modafinil nevirapine oxcarbazepine phenobarbital phenytoin pioglitazone rifabutin rifampin St. John’s wort |
alfentanil alprazolam amlodipine aprepitant aripiprazole artemisinin astemizole atazanavir atorvastatin bedaquiline buspirone cafergot chlorpheniramine cilostazol clarithromycin cocaine cyclosporine daclatasvir dapsone darunavir dexamethasone dextromethorphan diltiazem docetaxel domperidone elbasvir eplerenone |
erythromycin estradiol etravirine felodipine fentanyl finasteride fosamprenavir grazoprevir haloperidol hydrocortisone imitanib indinavir irinotecan lidocaine lovastatin maraviroc midazolam nateglinide nelfinavir nifedipine |
progesterone quetiapine quinidine quinine risperidone ritonavir salmeterol saquinavir sildenafil simeprevir simvastatin sirolimus tacrolimus tadalafil taxol terfenadine testosterone tipranavir trazodone triazolam vardenafil verapamil vincristine zaleplon ziprasidone zolpidem |
| CYP | Inhibitors | Inducers | Substrates | |||
