Multidrug-resistant organism: Difference between revisions
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* Microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents |
* Microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents |
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* Definition varies from hospital to hospital or country to country |
* Definition varies from hospital to hospital or country to country |
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* Generally includes the following bacteria: |
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** Gram-positives |
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*** [[MRSA]] |
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*** [[VRE]] |
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*** Multidrug-resistant [[Streptococcus pneumoniae]] |
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** Gram-negatives: |
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*** [[ESBL]] and CPE |
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*** [[Acinetobacter baumannii complex]] |
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*** [[Stenotrophomonas maltophilia]] |
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*** [[Burkholderia cepacia]] |
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*** [[Ralstonia pickettii]] |
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=== European CDC Definitions === |
=== European CDC Definitions === |
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* Defined by the European CDC |
* Defined by the European CDC[[CiteRef::magiorakos2012mu]] as non-susceptibility to at least one agent in three or more categories of antimicrobials, with the categories varying by organism |
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* Multidrug resistant (MDR) is non-susceptible to at least 1 agent in at least 3 categories |
* Multidrug resistant (MDR) is non-susceptible to at least 1 agent in at least 3 categories |
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** For [[Staphylococcus aureus]], it automatically includes MRSA, but requires resistance in >3 categories |
** For [[Staphylococcus aureus]], it automatically includes MRSA, but requires resistance in >3 categories |
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Latest revision as of 17:08, 27 September 2024
Background
- Microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents
- Definition varies from hospital to hospital or country to country
European CDC Definitions
- Defined by the European CDC1 as non-susceptibility to at least one agent in three or more categories of antimicrobials, with the categories varying by organism
- Multidrug resistant (MDR) is non-susceptible to at least 1 agent in at least 3 categories
- For Staphylococcus aureus, it automatically includes MRSA, but requires resistance in >3 categories
- Extensively drug-resistant (XDR) is non-susceptible to at least 1 agent in all but 2 categories
- Pan-drug resistant (PDR) is non-susceptible to all listed agents
- For species with intrinsic resistance to a category or agent, it should be excluded before counting
References
- ^ A.-P. Magiorakos, A. Srinivasan, R.B. Carey, Y. Carmeli, M.E. Falagas, C.G. Giske, S. Harbarth, J.F. Hindler, G. Kahlmeter, B. Olsson-Liljequist, D.L. Paterson, L.B. Rice, J. Stelling, M.J. Struelens, A. Vatopoulos, J.T. Weber, D.L. Monnet. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical Microbiology and Infection. 2012;18(3):268-281. doi:10.1111/j.1469-0691.2011.03570.x.
