Hypersensitivity reaction: Difference between revisions
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{| class="wikitable" |
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!Type |
! colspan="2" |Type |
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!Mechanism |
!Mechanism |
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!Examples |
!Examples |
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| colspan="2" |I |
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|I |
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|immediate IgE-mediated reaction |
|immediate IgE-mediated reaction |
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|[[anaphylaxis]], |
|[[anaphylaxis]], [[urticaria]], [[angioedema]], [[asthma]], [[allergic rhinitis]] |
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|- |
|- |
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| colspan="2" |II |
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|II |
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|antibody-mediated cytotoxic reaction |
|antibody-mediated cytotoxic reaction |
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|[[autoimmune hemolytic anemia]], [[pemphigus vulgaris]], [[Goodpasture syndrome]], [[myasthenia gravis]], [[Graves disease]] |
|[[autoimmune hemolytic anemia]], [[pemphigus vulgaris]], [[Goodpasture syndrome]], [[myasthenia gravis]], [[Graves disease]], [[chronic idiopathic urticaria]] |
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|- |
|- |
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|III |
| colspan="2" |III |
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|immune complex-mediated reaction |
|immune complex-mediated reaction |
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|[[systemic lupus erythematosus]], [[post-streptococcal glomerulonephritis]], [[serum sickness]] |
|[[systemic lupus erythematosus]], [[post-streptococcal glomerulonephritis]], [[serum sickness]], [[vasculitis]] |
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|- |
|- |
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| rowspan="5" |IV |
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|IV |
|IV |
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|delayed cell-mediated reaction |
|delayed cell-mediated reaction |
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== |
==Further Reading== |
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* |
*Classification of hypersensitivity reactions. ''Allergy Asthma Proc''. 2012;33:S96-S99. doi: [https://doi.org/10.2500/aap.2012.33.3561 10.2500/aap.2012.33.3561] |
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[[Category:Allergy]] |
[[Category:Allergy]] |
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Latest revision as of 17:51, 26 October 2023
| Type | Mechanism | Examples | |
|---|---|---|---|
| I | immediate IgE-mediated reaction | anaphylaxis, urticaria, angioedema, asthma, allergic rhinitis | |
| II | antibody-mediated cytotoxic reaction | autoimmune hemolytic anemia, pemphigus vulgaris, Goodpasture syndrome, myasthenia gravis, Graves disease, chronic idiopathic urticaria | |
| III | immune complex-mediated reaction | systemic lupus erythematosus, post-streptococcal glomerulonephritis, serum sickness, vasculitis | |
| IV | IV | delayed cell-mediated reaction | drug reaction with eosinophilia and systemic symptoms, multiple sclerosis, rheumatoid arthritis, sarcoidosis, tuberculosis |
| IVa | delayed Th1-mediated reaction | type 1 diabetes mellitus, contact dermatitis (with IVc) | |
| IVb | delayed Th2-mediated reaction | persistent asthma and allergic rhinitis | |
| IVc | delayed CD8 T-cell-mediated reaction | Stevens-Johnson syndrome and toxic epidermal necrolysis | |
| IVd | delayed T-cell-mediated neutrophilic reaction | acute generalized exanthematous pustulosis, Behçet syndrome | |
Further Reading
- Classification of hypersensitivity reactions. Allergy Asthma Proc. 2012;33:S96-S99. doi: 10.2500/aap.2012.33.3561
