Hypersensitivity reaction: Difference between revisions

Latest revision as of 17:51, 26 October 2023

Type		Mechanism	Examples
I		immediate IgE-mediated reaction	anaphylaxis, urticaria, angioedema, asthma, allergic rhinitis
II		antibody-mediated cytotoxic reaction	autoimmune hemolytic anemia, pemphigus vulgaris, Goodpasture syndrome, myasthenia gravis, Graves disease, chronic idiopathic urticaria
III		immune complex-mediated reaction	systemic lupus erythematosus, post-streptococcal glomerulonephritis, serum sickness, vasculitis
IV	IV	delayed cell-mediated reaction	drug reaction with eosinophilia and systemic symptoms, multiple sclerosis, rheumatoid arthritis, sarcoidosis, tuberculosis
	IVa	delayed Th1-mediated reaction	type 1 diabetes mellitus, contact dermatitis (with IVc)
	IVb	delayed Th2-mediated reaction	persistent asthma and allergic rhinitis
	IVc	delayed CD8 T-cell-mediated reaction	Stevens-Johnson syndrome and toxic epidermal necrolysis
	IVd	delayed T-cell-mediated neutrophilic reaction	acute generalized exanthematous pustulosis, Behçet syndrome

@@ Line 1: / Line 1: @@
 {| class="wikitable"
-!Type
+! colspan="2" |Type
 !Mechanism
 !Examples
 |-
+| colspan="2" |I
-|I
 |immediate IgE-mediated reaction
-|[[anaphylaxis]], allergies, [[asthma]]
+|[[anaphylaxis]], [[urticaria]], [[angioedema]], [[asthma]], [[allergic rhinitis]]
 |-
+| colspan="2" |II
-|II
 |antibody-mediated cytotoxic reaction
-|[[autoimmune hemolytic anemia]], [[pemphigus vulgaris]], [[Goodpasture syndrome]], [[myasthenia gravis]], [[Graves disease]]
+|[[autoimmune hemolytic anemia]], [[pemphigus vulgaris]], [[Goodpasture syndrome]], [[myasthenia gravis]], [[Graves disease]], [[chronic idiopathic urticaria]]
 |-
-|III
+| colspan="2" |III
 |immune complex-mediated reaction
-|[[systemic lupus erythematosus]], [[post-streptococcal glomerulonephritis]], [[serum sickness]]
+|[[systemic lupus erythematosus]], [[post-streptococcal glomerulonephritis]], [[serum sickness]], [[vasculitis]]
 |-
+| rowspan="5" |IV
 |IV
 |delayed cell-mediated reaction
-| rowspan="5" |[[drug reaction with eosinophilia and systemic symptoms]], [[poison ivy]], [[type 1 diabetes mellitus]], [[multiple sclerosis]], [[rheumatoid arthritis]], [[tuberculosis]]
+|[[drug reaction with eosinophilia and systemic symptoms]], [[multiple sclerosis]], [[rheumatoid arthritis]], [[sarcoidosis]], [[tuberculosis]]
 |-
 |IVa
 |delayed Th1-mediated reaction
+|[[type 1 diabetes mellitus]], [[contact dermatitis]] (with IVc)
 |-
 |IVb
 |delayed Th2-mediated reaction
+|persistent [[asthma]] and [[allergic rhinitis]]
 |-
 |IVc
 |delayed CD8 T-cell-mediated reaction
+|[[Stevens-Johnson syndrome]] and [[toxic epidermal necrolysis]]
 |-
 |IVd
 |delayed T-cell-mediated neutrophilic reaction
+|[[acute generalized exanthematous pustulosis]], [[Behçet syndrome]]
 |}
+==Further Reading==
+*Classification of hypersensitivity reactions. ''Allergy Asthma Proc''. 2012;33:S96-S99. doi: [https://doi.org/10.2500/aap.2012.33.3561 10.2500/aap.2012.33.3561]
 [[Category:Allergy]]