Drug-induced bullous pemphigoid
From IDWiki
- A form of severe cutaneous adverse reaction causing bullous pemphigoid
- Causative drugs include1
- Gliptins: alogliptin, anagliptin, linagliptin, sitagliptin, tenegliptin, vildagliptin
- Diuretics: furosemide; possibly spironolactone
- ACE inhibitors: enalapril
- Antibiotics: levofloxacin, rifampin; possibly with amoxicillin, ampicillin, cephalexin, ciprofloxacin, metronidazole, penicillin
- NSAIDs: aspirin, ibuprofen
- Others: Biostim, D-penicillamine, erlotinib, etanercept, everolimus, novilumab, pembrolizumab, phenacetin, Psoralens with UVA, serratiopeptidase, sirolimus, tetanus toxoid, tiobutarit
- Patients tend to be younger than classic bullous pemphigoid
- Lesions mostly appear on normal skin
- May have mucosal involvement of involvement of palms and soles
- May have Nikolsky sign
- Often have peripheral eosinophilia
- Symptoms can persist for up to 3 months after exposure
- Differential diagnosis includes HSV/VZV, erythema multiforme, pemphigus
References
- ^ M Verheyden, A Bilgic, D Murrell. A Systematic Review of Drug-Induced Pemphigoid. Acta Dermato Venereologica. 2020;100(15):adv00224. doi:10.2340/00015555-3457.
