Background
Microbiology
- Genus of Gram-negative bacilli that are oxidase negative and urease positive
- Part of the flora of the urinary and genital tracts as well as gastrointestinal tract
- Species of medical importance include Proteus mirabilis, Proteus vulgaris, and Proteus penneri
- Intrinsically resistant to tetracyclines, tigecycline, nitrofurantoin, and colistin
- Proteus penneri and Proteus vulgaris are also intrinsically resistant to ampicillin, and first- and second-generation cephalosporins
Clinical Manifestations
- Urinary tract infection
- Urease produces alkaline environment that can cause struvite stones
- Wound infections
- Pneumonia
- Bacteremia
