Immunodeficiency: Difference between revisions

Latest revision as of 20:07, 15 February 2023

Background

Usually organized into:
- Primary immunodeficiency
- Acquired (secondary) immunodeficiency
  - Includes immunosuppressive therapy

Clinical Manifestations

Immune Defect	Typical Infections	Typical Organisms
cell-mediated (T cells)	persistent viral infections, opportunistic infections, disseminated infections	Pneumocystis jirovecii, Cryptococcus, Herpesviridae
humoural (B cells)	respiratory infections with encapsulated organisms, chronic diarrhea, aseptic meningitis	Haemophilus influenzae, Streptococcus pneumoniae, Giardia lamblia, Campylobacter, enteroviruses
phagocytic	recurrent abscesses, gingivitis, aphthous ulcers	Staphylococcus aureus, Burkholderia cepacia, Serratia marcescens, Aspergillus, Nocardia
monocytic	disseminated infections and multifocal osteomyelitis	non-tuberculous mycobacteria, Salmonella, Histoplasma capsulatum, Coccidioides immitis
TLR	recurrent meningitis, bacteremia, absence of fever	Streptococcus pneumoniae, Neisseria meningitidis, Staphylococcus aureus, HSV
complement	recurrent bacteremia and meningitis	Neisseria
T cells and phagocytes	eczema, kyphoscoliosis, pathologic fratures, pulmonary and cutaneous infections, mucocutaneous candidiasis	Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Candida albicans

@@ Line 1: / Line 1: @@
+== Background ==
 * Usually organized into:
 ** [[Primary immunodeficiency]]
 ** [[Acquired immunodeficiency|Acquired (secondary) immunodeficiency]]
 *** Includes [[immunosuppressive therapy]]
+==Clinical Manifestations==
+{| class="wikitable"
+!Immune Defect
+!Typical Infections
+!Typical Organisms
+|-
+|cell-mediated (T cells)
+|persistent viral infections, opportunistic infections, disseminated infections
+|[[Pneumocystis jirovecii]], [[Cryptococcus]], [[Herpesviridae]]
+|-
+|humoural (B cells)
+|respiratory infections with [[Encapsulated bacteria|encapsulated organisms]], [[chronic diarrhea]], [[aseptic meningitis]]
+|[[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Giardia lamblia]], [[Campylobacter]], [[Enterovirus|enteroviruses]]
+|-
+|phagocytic
+|recurrent [[Abscess|abscesses]], [[gingivitis]], [[Aphthous ulcer|aphthous ulcers]]
+|[[Staphylococcus aureus]], [[Burkholderia cepacia]], [[Serratia marcescens]], [[Aspergillus]], [[Nocardia]]
+|-
+|monocytic
+|disseminated infections and multifocal [[osteomyelitis]]
+|[[non-tuberculous mycobacteria]], [[Salmonella]], [[Histoplasma capsulatum]], [[Coccidioides immitis]]
+|-
+|[[Toll-like receptors|TLR]]
+|recurrent [[meningitis]], [[bacteremia]], absence of fever
+|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Staphylococcus aureus]], [[HSV]]
+|-
+|complement
+|recurrent [[bacteremia]] and [[meningitis]]
+|[[Neisseria]]
+|-
+|T cells and phagocytes
+|[[eczema]], [[kyphoscoliosis]], pathologic fratures, pulmonary and cutaneous infections, [[mucocutaneous candidiasis]]
+|[[Staphylococcus aureus]], [[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Candida albicans]]
+|}
 [[Category:Immunology]]
 [[Category:Immunocompromised hosts]]