Drug-induced thrombotic microangiopathy
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Revision as of 09:59, 20 April 2023 by Aidan (talk | contribs) (Created page with "== Background == * A thrombotic microangiopathy caused by exposure to certain medications * May present with a TTP- or HUS-like syndrome * Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic * Associations that are probably true include: bevacizumab, cocaine, '''cyclosporine''', docetaxel, everolimus, gemcitabine, interferon α, interferon β, interferon polycarboxylate...")
Background
- A thrombotic microangiopathy caused by exposure to certain medications
- May present with a TTP- or HUS-like syndrome
- Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic
- Associations that are probably true include: bevacizumab, cocaine, cyclosporine, docetaxel, everolimus, gemcitabine, interferon α, interferon β, interferon polycarboxylate, mitomycin, muromonab-CD3, oxaliplatin, penicillin, pentostatin, quetiapine, quinine, sirolimus, sulfisoxazole, sunitinib, tacrolimus, trielina, and vincristine[1]
Further Reading
- Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood. 2015 Jan 22;125(4):616-8. doi: 10.1182/blood-2014-11-611335. PMID: 25414441; PMCID: PMC4304106.
- ↑ Al-Nouri ZL, Reese JA, Terrell DR, Vesely SK, George JN. Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood. 2015 Jan 22;125(4):616-8. doi: 10.1182/blood-2014-11-611335. Epub 2014 Nov 20. PMID: 25414441; PMCID: PMC4304106.
