- Mosquito-borne Flavivirus endemic in tropics worldwide
- Transmitted by Aedes aegypti and Aedes albopictus
- Incubation period of 4 to 7 days
- Classic presentation includes fever, headache (especially retroorbital), diffuse arthralgias ("breakbone fever"), and rash
- Often has thrombocytopenia
- Differential also include whichever rickettsioses are endemic to the area visited
