Dengue virus: Difference between revisions
From IDWiki
m (Text replacement - "Category:Vector-borne diseases" to "Category:Vector-borne infections") |
(→) |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
| − | == |
+ | ==Background== |
| − | === |
+ | ===Microbiology=== |
*Single-stranded positive-sense RNA virus |
*Single-stranded positive-sense RNA virus |
||
*Member of the [[Flaviviridae]] |
*Member of the [[Flaviviridae]] |
||
| − | === |
+ | ===Epidemiology=== |
| − | * |
+ | *Endemic in tropics worldwide, with almost half of the world's population at risk of infection |
| − | * |
+ | *Transmitted by ''[[Vector::Aedes aegypti]]'' and ''[[Vector::Aedes albopictus]]'' |
| − | == |
+ | ==Clinical Manifestations== |
*Incubation period of [[Usual incubation period::4 to 7 days]] |
*Incubation period of [[Usual incubation period::4 to 7 days]] |
||
*Classic presentation includes [[Causes::fever]], [[Causes::headache]] (especially retroorbital), diffuse [[Causes::arthralgias]] ("breakbone fever"), and [[Causes::rash]] |
*Classic presentation includes [[Causes::fever]], [[Causes::headache]] (especially retroorbital), diffuse [[Causes::arthralgias]] ("breakbone fever"), and [[Causes::rash]] |
||
*Often has [[Causes::thrombocytopenia]] |
*Often has [[Causes::thrombocytopenia]] |
||
| + | *With repeated infections, can progress to [[Causes::hemorrhagic fever]] and [[Causes::shock]] |
||
| − | == |
+ | ==Differential Diagnosis== |
| + | *[[Zika virus]] |
||
| − | *Differential also include whichever [[rickettsioses]] are endemic to the area visited |
||
| + | *[[Chikungunya virus]] |
||
| + | *[[Rickettsiae]] |
||
| + | {| class="wikitable" |
||
| ⚫ | |||
| + | !Feature |
||
| + | !Dengue |
||
| + | ![[Zika]] |
||
| + | ![[Chikungunya]] |
||
| + | |- |
||
| + | |Asymptomatic |
||
| + | |40-80% |
||
| + | |35-85% |
||
| + | |3-28% |
||
| + | |- |
||
| + | |Fever |
||
| + | | +++ |
||
| + | | ++ |
||
| + | | +++ |
||
| + | |- |
||
| + | |Rash |
||
| + | | + |
||
| + | | +++ |
||
| + | | ++ |
||
| + | |- |
||
| + | |Conjunctivitis |
||
| + | |– |
||
| + | | ++ |
||
| + | | + |
||
| + | |- |
||
| + | |Arthralgia |
||
| + | | + |
||
| + | | ++ |
||
| + | | +++ |
||
| + | |- |
||
| + | |Myalgia |
||
| + | | ++ |
||
| + | | + |
||
| + | | + |
||
| + | |- |
||
| + | |Headache |
||
| + | | ++ |
||
| + | | + |
||
| + | | ++ |
||
| + | |- |
||
| + | |Hemorrhage |
||
| + | | ++ |
||
| + | |– |
||
| + | |– |
||
| + | |- |
||
| + | |Shock |
||
| + | | + |
||
| + | |– |
||
| + | |– |
||
| + | |- |
||
| + | |Thrombocytopenia |
||
| + | | +++ |
||
| + | | + |
||
| + | |– |
||
| + | |- |
||
| + | |Leukopenia |
||
| + | | ++ |
||
| + | |– |
||
| + | | ++ |
||
| + | |} |
||
| ⚫ | |||
| ⚫ | |||
| + | |||
| ⚫ | |||
[[Category:Flaviviridae]] |
[[Category:Flaviviridae]] |
||
Latest revision as of 14:11, 22 August 2020
Background
Microbiology
- Single-stranded positive-sense RNA virus
- Member of the Flaviviridae
Epidemiology
- Endemic in tropics worldwide, with almost half of the world's population at risk of infection
- Transmitted by Aedes aegypti and Aedes albopictus
Clinical Manifestations
- Incubation period of 4 to 7 days
- Classic presentation includes fever, headache (especially retroorbital), diffuse arthralgias ("breakbone fever"), and rash
- Often has thrombocytopenia
- With repeated infections, can progress to hemorrhagic fever and shock
Differential Diagnosis
| Feature | Dengue | Zika | Chikungunya |
|---|---|---|---|
| Asymptomatic | 40-80% | 35-85% | 3-28% |
| Fever | +++ | ++ | +++ |
| Rash | + | +++ | ++ |
| Conjunctivitis | – | ++ | + |
| Arthralgia | + | ++ | +++ |
| Myalgia | ++ | + | + |
| Headache | ++ | + | ++ |
| Hemorrhage | ++ | – | – |
| Shock | + | – | – |
| Thrombocytopenia | +++ | + | – |
| Leukopenia | ++ | – | ++ |
Management
- Supportive
