Dengue virus: Difference between revisions
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+ | ==Background== |
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− | * Mosquito-borne Flavivirus endemic in tropics worldwide |
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+ | |||
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+ | ===Microbiology=== |
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+ | |||
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+ | *Single-stranded positive-sense RNA virus |
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+ | *Member of the [[Flaviviridae]] |
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− | * Differential also include whichever [[rickettsioses]] are endemic to the area visited |
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+ | |||
+ | ===Epidemiology=== |
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+ | |||
+ | *Endemic in tropics worldwide, with almost half of the world's population at risk of infection |
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+ | |||
+ | ==Clinical Manifestations== |
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+ | |||
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+ | *With repeated infections, can progress to [[Causes::hemorrhagic fever]] and [[Causes::shock]] |
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+ | |||
+ | ==Differential Diagnosis== |
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+ | |||
+ | *[[Zika virus]] |
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+ | *[[Chikungunya virus]] |
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+ | *[[Rickettsiae]] |
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+ | |||
+ | {| class="wikitable" |
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+ | !Feature |
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+ | !Dengue |
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+ | ![[Zika]] |
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+ | ![[Chikungunya]] |
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+ | |- |
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+ | |Asymptomatic |
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+ | |40-80% |
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+ | |35-85% |
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+ | |3-28% |
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+ | |- |
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+ | |Fever |
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+ | | +++ |
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+ | | ++ |
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+ | | +++ |
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+ | |- |
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+ | |Rash |
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+ | | + |
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+ | | +++ |
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+ | | ++ |
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+ | |- |
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+ | |Conjunctivitis |
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+ | |– |
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+ | | ++ |
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+ | | + |
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+ | |- |
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+ | |Arthralgia |
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+ | | + |
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+ | | ++ |
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+ | | +++ |
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+ | |- |
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+ | |Myalgia |
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+ | | ++ |
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+ | | + |
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+ | | + |
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+ | |- |
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+ | |Headache |
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+ | | ++ |
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+ | | + |
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+ | | ++ |
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+ | |- |
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+ | |Hemorrhage |
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+ | | ++ |
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+ | |– |
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+ | |– |
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+ | |- |
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+ | |Shock |
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+ | | + |
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+ | |– |
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+ | |– |
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+ | |- |
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+ | |Thrombocytopenia |
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+ | | +++ |
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+ | | + |
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+ | |– |
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+ | |- |
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+ | |Leukopenia |
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+ | | ++ |
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+ | |– |
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+ | | ++ |
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+ | |} |
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+ | |||
+ | ==Management== |
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+ | |||
+ | *Supportive |
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[[Category:Flaviviridae]] |
[[Category:Flaviviridae]] |
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+ | [[Category:Vector-borne infections]] |
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+ | [[Category:Infectious diseases]] |
Latest revision as of 14:11, 22 August 2020
Background
Microbiology
- Single-stranded positive-sense RNA virus
- Member of the Flaviviridae
Epidemiology
- Endemic in tropics worldwide, with almost half of the world's population at risk of infection
- Transmitted by Aedes aegypti and Aedes albopictus
Clinical Manifestations
- Incubation period of 4 to 7 days
- Classic presentation includes fever, headache (especially retroorbital), diffuse arthralgias ("breakbone fever"), and rash
- Often has thrombocytopenia
- With repeated infections, can progress to hemorrhagic fever and shock
Differential Diagnosis
Feature | Dengue | Zika | Chikungunya |
---|---|---|---|
Asymptomatic | 40-80% | 35-85% | 3-28% |
Fever | +++ | ++ | +++ |
Rash | + | +++ | ++ |
Conjunctivitis | – | ++ | + |
Arthralgia | + | ++ | +++ |
Myalgia | ++ | + | + |
Headache | ++ | + | ++ |
Hemorrhage | ++ | – | – |
Shock | + | – | – |
Thrombocytopenia | +++ | + | – |
Leukopenia | ++ | – | ++ |
Management
- Supportive