Corynebacterium jeikeium: Difference between revisions

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Corynebacterium jeikeium
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* Species of [[Corynebacterium|''Corynebacterium'']] that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
  
* Species of [[Corynebacterium|''Corynebacterium'']] that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
 
* Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
  
* Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
  +
* Essentially universally susceptible to [[vancomycin]] and [[linezolid]]
−  
  +
* High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible<ref name=":0">Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV, Patel SN. ''In Vitro'' Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01776-17. doi: [https://doi.org/10.1128/aac.01776-17 10.1128/AAC.01776-17]. PMID: [https://pubmed.ncbi.nlm.nih.gov/29339389/ 29339389]; PMCID: [http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5914010/ PMC5914010].</ref>
  +
{| class="wikitable sortable"
  +
|+From <ref name=":0" />
  +
!Antibiotic
  +
!Isolates
  +
!% Susceptible
  +
|-
  +
|[[Penicillin]]
  +
|76
  +
|0
  +
|-
  +
|[[Ampicillin]]
  +
|76
  +
|ND
  +
|-
  +
|[[Oxacillin]]
  +
|76
  +
|ND
  +
|-
  +
|[[Erythromycin]]
  +
|76
  +
|11.8
  +
|-
  +
|[[Clindamycin]]
  +
|76
  +
|2.6
  +
|-
  +
|[[Ciprofloxacin]]
  +
|75
  +
|35.5
  +
|-
  +
|[[Levofloxacin]]
  +
|75
  +
|ND
  +
|-
  +
|[[Moxifloxacin]]
  +
|76
  +
|35.5
  +
|-
  +
|'''[[Tetracycline]]'''
  +
|'''76'''
  +
|'''92.1'''
  +
|-
  +
|'''[[Vancomycin]]'''
  +
|'''76'''
  +
|'''100'''
  +
|-
  +
|[[Trimethoprim-sulfamethoxazole]]
  +
|76
  +
|18.4
  +
|-
  +
|[[Tigecycline]]
  +
|76
  +
|ND
  +
|-
  +
|'''[[Rifampin]]'''
  +
|'''76'''
  +
|'''97.4'''
  +
|-
  +
|'''[[Quinupristin-dalfopristin]]'''
  +
|'''76'''
  +
|'''89.5'''
  +
|-
  +
|'''[[Linezolid]]'''
  +
|'''76'''
  +
|'''100'''
  +
|-
  +
|'''[[Gentamicin]]'''
  +
|'''76'''
  +
|'''81.6'''
  +
|-
  +
|'''[[Daptomycin]]'''
  +
|'''75'''
  +
|'''89.5'''
  +
|-
  +
|[[Chloramphenicol]]
  +
|75
  +
|ND
  +
|-
  +
|[[Nitrofurantoin]]
  +
|76
  +
|ND
  +
|}
  +
{| class="wikitable"
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|Penicillin
  +
|76
  +
|0.5 to >8
  +
|>8
  +
|>8
  +
|0
  +
|-
  +
|    Ampicillin
  +
|76
  +
|≤0.12 to >8
  +
|>8
  +
|>8
  +
|ND
  +
|-
  +
|    Oxacillin
  +
|76
  +
|0.5 to >4
  +
|>4
  +
|>4
  +
|ND
  +
|-
  +
|    Erythromycin
  +
|76
  +
|≤0.25 to >4
  +
|>4
  +
|>4
  +
|11.8
  +
|-
  +
|    Clindamycin
  +
|76
  +
|≤0.5 to >2
  +
|>2
  +
|>2
  +
|2.6
  +
|-
  +
|    Ciprofloxacin
  +
|75
  +
|≤1 to >2
  +
|>2
  +
|>2
  +
|35.5
  +
|-
  +
|    Levofloxacin
  +
|75
  +
|≤0.25 to >4
  +
|>4
  +
|>4
  +
|ND
  +
|-
  +
|    Moxifloxacin<sup>''b''</sup>
  +
|76
  +
|≤0.25 to >4
  +
|4
  +
|>4
  +
|35.5
  +
|-
  +
|    Tetracycline
  +
|76
  +
|≤2 to >16
  +
|≤2
  +
|≤2
  +
|92.1
  +
|-
  +
|    Vancomycin
  +
|76
  +
|≤0.25 to 2
  +
|0.50
  +
|1
  +
|100
  +
|-
  +
|    Trimethoprim-sulfamethoxazole
  +
|76
  +
|≤0.5 to >4
  +
|>4
  +
|>4
  +
|18.4
  +
|-
  +
|    Tigecycline
  +
|76
  +
|≤0.03 to >0.5
  +
|0.12
  +
|0.25
  +
|ND
  +
|-
  +
|    Rifampin
  +
|76
  +
|≤0.5 to >4
  +
|≤0.5
  +
|≤0.5
  +
|97.4
  +
|-
  +
|    Quinupristin-dalfopristin
  +
|76
  +
|≤0.5 to 4
  +
|≤0.5
  +
|2
  +
|89.5
  +
|-
  +
|    Linezolid
  +
|76
  +
|≤1
  +
|≤1
  +
|≤1
  +
|100
  +
|-
  +
|    Gentamicin
  +
|76
  +
|≤2 to >16
  +
|≤2
  +
|>16
  +
|81.6
  +
|-
  +
|    Daptomycin
  +
|75
  +
|≤0.5 to >4
  +
|≤0.5
  +
|1
  +
|89.5
  +
|-
  +
|    Chloramphenicol
  +
|75
  +
|≤2 to >16
  +
|4
  +
|16
  +
|ND
  +
|-
  +
|    Nitrofurantoin
  +
|76
  +
|≤32 to >64
  +
|>64
  +
|>64
  +
|ND
  +
|}
 
{{DISPLAYTITLE:''Corynebacterium jeikeium''}}
  
{{DISPLAYTITLE:''Corynebacterium jeikeium''}}
 
[[Category:Gram-positive bacilli]]
  
[[Category:Gram-positive bacilli]]

Revision as of 10:37, 27 September 2023

  • Species of Corynebacterium that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
  • Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
  • Essentially universally susceptible to vancomycin and linezolid
  • High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible[1]
From [1]
Antibiotic Isolates % Susceptible
Penicillin 76 0
Ampicillin 76 ND
Oxacillin 76 ND
Erythromycin 76 11.8
Clindamycin 76 2.6
Ciprofloxacin 75 35.5
Levofloxacin 75 ND
Moxifloxacin 76 35.5
Tetracycline 76 92.1
Vancomycin 76 100
Trimethoprim-sulfamethoxazole 76 18.4
Tigecycline 76 ND
Rifampin 76 97.4
Quinupristin-dalfopristin 76 89.5
Linezolid 76 100
Gentamicin 76 81.6
Daptomycin 75 89.5
Chloramphenicol 75 ND
Nitrofurantoin 76 ND
Penicillin 76 0.5 to >8 >8 >8 0
    Ampicillin 76 ≤0.12 to >8 >8 >8 ND
    Oxacillin 76 0.5 to >4 >4 >4 ND
    Erythromycin 76 ≤0.25 to >4 >4 >4 11.8
    Clindamycin 76 ≤0.5 to >2 >2 >2 2.6
    Ciprofloxacin 75 ≤1 to >2 >2 >2 35.5
    Levofloxacin 75 ≤0.25 to >4 >4 >4 ND
    Moxifloxacinb 76 ≤0.25 to >4 4 >4 35.5
    Tetracycline 76 ≤2 to >16 ≤2 ≤2 92.1
    Vancomycin 76 ≤0.25 to 2 0.50 1 100
    Trimethoprim-sulfamethoxazole 76 ≤0.5 to >4 >4 >4 18.4
    Tigecycline 76 ≤0.03 to >0.5 0.12 0.25 ND
    Rifampin 76 ≤0.5 to >4 ≤0.5 ≤0.5 97.4
    Quinupristin-dalfopristin 76 ≤0.5 to 4 ≤0.5 2 89.5
    Linezolid 76 ≤1 ≤1 ≤1 100
    Gentamicin 76 ≤2 to >16 ≤2 >16 81.6
    Daptomycin 75 ≤0.5 to >4 ≤0.5 1 89.5
    Chloramphenicol 75 ≤2 to >16 4 16 ND
    Nitrofurantoin 76 ≤32 to >64 >64 >64 ND
  1. ↑ 1.0 1.1 Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV, Patel SN. In Vitro Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01776-17. doi: 10.1128/AAC.01776-17. PMID: 29339389; PMCID: PMC5914010.
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