Anemia: Difference between revisions
From IDWiki
(Imported from text file) |
|||
(2 intermediate revisions by the same user not shown) | |||
Line 4: | Line 4: | ||
* [[Iron-deficiency anemia]] |
* [[Iron-deficiency anemia]] |
||
− | * Thalassemia |
+ | * [[Thalassemia]] |
− | * Anemia of chronic inflammation (ferritin < 100 and |
+ | * [[Anemia of chronic inflammation]] ([[ferritin]] < 100 and [[transferrin saturation]] < 20%) |
− | * Lead poisoning |
+ | * [[Lead poisoning]] |
− | * Sideroblastic anemia |
+ | * [[Sideroblastic anemia]] |
=== Normocytic anemia (MCV 80-100) === |
=== Normocytic anemia (MCV 80-100) === |
||
* Elevated reticulocytes (normal marrow response) |
* Elevated reticulocytes (normal marrow response) |
||
− | ** Hemolytic anemia |
+ | ** [[Hemolytic anemia]] |
*** Intrinsic RBC defect |
*** Intrinsic RBC defect |
||
− | **** Hemoglobinopathy |
+ | **** [[Hemoglobinopathy]] |
− | **** Enzymopathy: G6PD deficiency |
+ | **** Enzymopathy: [[G6PD deficiency]] |
**** Membrane-cytoskeletal defects |
**** Membrane-cytoskeletal defects |
||
− | ***** Hereditary spherocytosis |
+ | ***** [[Hereditary spherocytosis]] |
− | ***** Hereditary elliptocytosis |
+ | ***** [[Hereditary elliptocytosis]] |
**** [[Paroxysmal nocturnal hemoglobinuria]] |
**** [[Paroxysmal nocturnal hemoglobinuria]] |
||
*** Extracorpuscular |
*** Extracorpuscular |
||
**** [[Microangiopathic hemolytic anemia]] |
**** [[Microangiopathic hemolytic anemia]] |
||
− | **** Drugs and toxins: oxygen, nitrates, chlorates, methylene blue, dapsone, cisplatin, arsine, copper, lead |
+ | **** Drugs and toxins: oxygen, nitrates, chlorates, [[methylene blue]], [[dapsone]], [[cisplatin]], arsine, copper, lead |
− | **** Infections: malaria, HUS, |
+ | **** Infections: [[malaria]], [[HUS]], [[Clostridium perfringens]] |
**** [[Autoimmune hemolytic anemia]] |
**** [[Autoimmune hemolytic anemia]] |
||
***** Cold and warm AIHA |
***** Cold and warm AIHA |
||
* Low or inappropriately normal reticulocytes (poor marrow response or low erythropoietin) |
* Low or inappropriately normal reticulocytes (poor marrow response or low erythropoietin) |
||
− | ** Chronic kidney disease |
+ | ** [[Chronic kidney disease]] |
=== Macrocytic anemia (MCV >100) === |
=== Macrocytic anemia (MCV >100) === |
||
− | * Megaloblastic |
+ | * [[Megaloblastic anemia|Megaloblastic]] |
* Non-megaloblastic |
* Non-megaloblastic |
||
== Investigations == |
== Investigations == |
||
⚫ | |||
− | |||
+ | ** MCHC increased in HS and Hb SS |
||
− | * Bloodwork |
||
⚫ | |||
⚫ | |||
− | + | ** RDW increased in iron deficiency, reticulocytosis, blood transfusion |
|
⚫ | |||
⚫ | |||
⚫ | |||
− | *** RDQ increased in IDA, reticulocytosis, blood transfusion |
||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
− | * Imaging |
||
− | * Other |
||
− | |||
[[Category:Hematology]] |
[[Category:Hematology]] |
||
[[Category:Investigation]] |
[[Category:Investigation]] |
Latest revision as of 16:13, 30 August 2023
Differential Diagnosis
Microcytic anemia (MCV <80)
- Iron-deficiency anemia
- Thalassemia
- Anemia of chronic inflammation (ferritin < 100 and transferrin saturation < 20%)
- Lead poisoning
- Sideroblastic anemia
Normocytic anemia (MCV 80-100)
- Elevated reticulocytes (normal marrow response)
- Hemolytic anemia
- Intrinsic RBC defect
- Hemoglobinopathy
- Enzymopathy: G6PD deficiency
- Membrane-cytoskeletal defects
- Paroxysmal nocturnal hemoglobinuria
- Extracorpuscular
- Microangiopathic hemolytic anemia
- Drugs and toxins: oxygen, nitrates, chlorates, methylene blue, dapsone, cisplatin, arsine, copper, lead
- Infections: malaria, HUS, Clostridium perfringens
- Autoimmune hemolytic anemia
- Cold and warm AIHA
- Intrinsic RBC defect
- Hemolytic anemia
- Low or inappropriately normal reticulocytes (poor marrow response or low erythropoietin)
Macrocytic anemia (MCV >100)
- Megaloblastic
- Non-megaloblastic
Investigations
- CBC with differential
- MCHC increased in HS and Hb SS
- MCH decreased in hypochromic anemias
- RDW increased in iron deficiency, reticulocytosis, blood transfusion
- Reticulocyte count (normally 1-2%)
- Peripheral blood film
- Ferritin, transferrin saturation
- Vitamin B12
- SPEP, and UPEP or serum free light chains