Etiology
- Infection: especially common in children
- Mycoplasma pneumoniae: moderate to severe involvement of two or more mucosal sites and sparse, or even absent, skin involvement
- Neisseria gonorrhoeae1
- Drugs
- Allopurinol
- Aromatic antiepileptic drugs and lamotrigine
- Antibacterial sulfonamides (including sulfamethoxazole and sulfasalazine)
- Nevirapine
- Oxicam nonsteroidal anti-inflammatory drugs (NSAIDs)
- Less strongly, other antibiotics
Management
- Risk stratify with SCORTEN score
- Consider referral to burn centre or ICU
References
- ^ SK Tan, YK Tay. Profile and Pattern of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a General Hospital in Singapore: Treatment Outcomes. Acta Dermato Venereologica. 2012;92(1):62-66. doi:10.2340/00015555-1169.
