Pharmacokinetics and pharmacodynamics

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Background

Pharmacokinetics refers to the movement of drug through the body, and is characterized by absorption, distribution, metabolism, and excretion
Pharmacodynamics refers to the effect of the drug on the body

Antimicrobials

Antimicrobial	Bactericidal Pattern	PK-PD Measure
aminoglycosides	concentration-dependent	AUC_0-24:MIC, C_max:MIC
β-lactams	time-dependent	T>MIC
clindamycin	time-dependent	AUC_0-24:MIC
daptomycin	concentration-dependent	AUC_0-24:MIC, C_max:MIC
vancomycin	time-dependent	AUC_0-24:MIC
azithromycin	time-dependent	AUC_0-24:MIC
clarithromycin	time-dependent	AUC_0-24:MIC
metronidazole	concentration-dependent	AUC_0-24:MIC, C_max:MIC
linezolid	time-dependent	AUC_0-24:MIC
fluoroquinolones	concentration-dependent	AUC_0-24:MIC, C_max:MIC
doxycycline	time-dependent	AUC_0-24:MIC
tigecycline	time-dependent	AUC_0-24:MIC

Further Reading

Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore. Clin Infect Dis. 2007;44(1):79-86. doi: 10.1086/510079

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