Parasitic brain infections

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Differential Diagnosis

Parasite Disease Lesion Location
Protozoa
Balamuthia mandrillaris and Acanthamoeba species Granulomatous amoebic encephalitis single or multiple ring-enhancing lesions with surrounding edema and mass effect gray and white matter
Leishmania species Leishmaniasis
Microsporidia species Microsporidiasis
Naegleria fowleri Primary amebic meningoencephalitis global edema, stroke, and elevated intracranial pressure base of brain most common
Plasmodium species Malaria
Toxoplasma gondii Toxoplasmosis
Trypanosoma brucei African trypanosomiasis diffuse hyperintensity on T1 bilateral basal ganglia
Trypanosoma cruzi Chagas disease contrast-enhancing hypointense T1 lesions with edema on T2 parietal and frontal lobes only
Metazoa: Trematodes
Paragonimus species Paragonimiasis inflammatory changes surrounding clusters of contrast-enhancing lesions frontal and temporal gray and white matter most common
Schistosoma species Schistosomiasis central linear enhancement, clustered with arborized appearance can include spinal cord, especially with Schistosoma haematobium
Metazoa: Cestodes
Echinococcus granulosus Intracranial hydatidosis multiple thin-walled, large, round cysts, or one large cyst with smaller surrounding cysts parietal most common
Echinococcus multilocularis Alveolar hydatid disease contrast-enhancing round, solid lesions with surrounding edema on T2 any
Taenia solium Neurocysticercosis single or multiple ring-enhancing lesions, with calcifications if older
Taenia species Coenurosis
Spirometra species Sparganosis T2 edema, sometimes with T1 mass or linear or curvilinear contrast-enhancing lesions frontal and parietal lobes most common
Metazoa: Nematodes
Gnathostoma species Gnathostomiasis
Angiostrongylus cantonensis Angiostrongyliasis
Toxocara species Toxocariasis
Strongyloides stercoralis Strongyloidiasis
multiple Filariasis
Baylisascaris procyonis Baylisascariasis
Dracuncula medinensis Dracunculiasis
Dicrocoelium dendriticum Dicrocoeliasis
Lagochilascaris species Lagochilascariasis