Acinetobacter baumannii complex
From IDWiki
Background
Microbiology
- Contains Acinetobacter baumannii, Acinetobacter nosocomialis, and Acinetobacter pittii
- Non-motile, non-fermenting Gram-negative bacillus
Antimicrobial Resistance
- A number of mechanisms
- Carbapenem resistance is usually mediated by acquisition of OXA-type class D carbapenemase
- Less common mechanisms include acquisition of class B (VIM, IMP, and NDM) carbapenemases, loss of outer membrane CarO protein, and modification of AdeABC efflux pump
Management
- Choice of antibiotic depends on susceptibility testing
- Possible options include:
- Cefepime, ceftriaxone, and cefotaxime
- Cefiderocol
- Carbapenems
- Tigecycline
- Colistin and polymyxin B (though Acinetobacter junii has inherent resistance)
- Aminoglycosides may not penetrate well into lungs and brain, so are usually avoided
- Bacteriophages are promising
Carbapenem-Resistant Acinetobacter baumannii
- Infection must be distinguished from colonization of the airway or wound
- Resistance may be mediated by a number of β-lactamases, including OXA-24/40-like carbapenemases, OXA-23-like carbapenemases, and metallo-β-lactamases, and often has sulbactam resistance
- Often have concurrent aminoglycoside-modifying enzymes or 16S rRNA methyltransferases, which confer resistance to aminoglycosides including plazomicin
- Refer to ESCMID guidelines1
- Single-agent treatment may be sufficient for mild infections
- High-dose ampicillin-sulbactam is preferred, at a dose of either 9 g IV q8h infused over 4 hours, or 27 g IV q24h continuous infusion
- If susceptible, polymixin B or high-dose tigecycline
- Combination treatment with at least two agents that have in vitro activity for most other infections
- Options include minocycline, tigecycline, aminoglycosides, or polymyxin B
- Ampicillin-sulbactam may remain effective in non-susceptible isolates when used at high doses
- Fosfomycin and rifampin are not recommended
- After clinical improvement, step down to single-agent therapy
- Cefiderocol should generally be avoided
References
- ^ Mical Paul, Elena Carrara, Pilar Retamar, Thomas Tängdén, Roni Bitterman, Robert A. Bonomo, Jan de Waele, George L. Daikos, Murat Akova, Stephan Harbarth, Celine Pulcini, José Garnacho-Montero, Katja Seme, Mario Tumbarello, Paul Christoffer Lindemann, Sumanth Gandra, Yunsong Yu, Matteo Bassetti, Johan W. Mouton, Evelina Tacconelli, Jesús Rodríguez-Baño. European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine). Clinical Microbiology and Infection. 2022;28(4):521-547. doi:10.1016/j.cmi.2021.11.025.