Corynebacterium jeikeium

• Species of Corynebacterium that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
• Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
• Essentially universally susceptible to vancomycin and linezolid
• High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible

From

Antibiotic	Isolates	% Susceptible
Penicillin	76	0
Ampicillin	76	ND
Oxacillin	76	ND
Erythromycin	76	11.8
Clindamycin	76	2.6
Ciprofloxacin	75	35.5
Levofloxacin	75	ND
Moxifloxacin	76	35.5
Tetracycline	76	92.1
Vancomycin	76	100
Trimethoprim-sulfamethoxazole	76	18.4
Tigecycline	76	ND
Rifampin	76	97.4
Quinupristin-dalfopristin	76	89.5
Linezolid	76	100
Gentamicin	76	81.6
Daptomycin	75	89.5
Chloramphenicol	75	ND
Nitrofurantoin	76	ND

Penicillin	76	0.5 to >8	>8	>8	0
Ampicillin	76	≤0.12 to >8	>8	>8	ND
Oxacillin	76	0.5 to >4	>4	>4	ND
Erythromycin	76	≤0.25 to >4	>4	>4	11.8
Clindamycin	76	≤0.5 to >2	>2	>2	2.6
Ciprofloxacin	75	≤1 to >2	>2	>2	35.5
Levofloxacin	75	≤0.25 to >4	>4	>4	ND
Moxifloxacinb	76	≤0.25 to >4	4	>4	35.5
Tetracycline	76	≤2 to >16	≤2	≤2	92.1
Vancomycin	76	≤0.25 to 2	0.50	1	100
Trimethoprim-sulfamethoxazole	76	≤0.5 to >4	>4	>4	18.4
Tigecycline	76	≤0.03 to >0.5	0.12	0.25	ND
Rifampin	76	≤0.5 to >4	≤0.5	≤0.5	97.4
Quinupristin-dalfopristin	76	≤0.5 to 4	≤0.5	2	89.5
Linezolid	76	≤1	≤1	≤1	100
Gentamicin	76	≤2 to >16	≤2	>16	81.6
Daptomycin	75	≤0.5 to >4	≤0.5	1	89.5
Chloramphenicol	75	≤2 to >16	4	16	ND
Nitrofurantoin	76	≤32 to >64	>64	>64	ND