Carbapenem-resistant organisms

Background

• Mechanisms include decreased expression of porins, increased expression of efflux pumps, and carbapenemases

Management

Novel Antibiotics

Antibiotic	KPC	NDM	OXA-48	CRPsA	CRAcB	Stenotrophomonas
aztreonam-avibactam	+	+	+	±	–	+
cefiderocol	+	+	+	+	+	+
ceftazidime-avibactam	+	–	+	±	–	–
ceftolozane-tazobactam	–	–	–	±	–	±
eravacycline	+	+	+	–	+	+
fosfomycin	±	±	±	±	–	–
imipenem-relebactam	+	–	±	+	–	–
meropenem-vaborbactam	+	–	–	–	–	–
plazomicin	+	±	+	±	–	–
colistin	±	±	±	±	±	±
tigecycline	+	+	+	–	+	+