| Test
|
Association
|
Correlates with dz activity?
|
| ANA
|
SLE
|
No
|
| ANA (centromere pattern)
|
CREST syndrome, SSc, PH
|
|
| Anti-Smith
|
SLE (most specific)
|
No
|
| Anti-dsDNA
|
SLE
|
Yes, especially renal disease
|
| Anti-histone
|
Drug-induced lupus
|
|
| Anti-U1-RNP
|
Mixed CTD
|
|
| Anti-Ro/SS-A
|
Sjögren syndrome, neonatal heart block, subacute SLE
|
|
| Anti-Ro/SS-A 60 kDa
|
|
|
| Anti-Ro/SS-A 52 kDa
|
Systemic sclerosis and SLE, often with other antibodies present1
|
|
| Anti-La/SSB
|
Sjögren syndrome, sicca syndrome, neonatal SLE
|
|
| Anti-Scl-70
|
SSc and pulmonary fibrosis, dcSSc
|
|
| Anti-Jo-1
|
Polymyositis, antisynthetase syndrome
|
|
| Anti-CCP
|
RA (most specific)
|
|
| Anti-smooth muscle
|
Autoimmune hepatitis
|
|
| Anti-PR3 (cANCA)
|
GPA
|
|
| Anti-MPO (pANCA)
|
MPA and eGPA
|
|
| Anti-parietal cell antibodies
|
Autoimmune gastritis and pernicious anemia; also Addison disease, autoimmune thyroiditis, type 1 diabetes mellitus, and primary ovarian failure
|
|
