Rheumatologic serologies
From IDWiki
| Test | Association | Correlates with dz activity? |
|---|---|---|
| ANA | SLE | No |
| ANA (centromere pattern) | CREST syndrome, SSc, PH | |
| Anti-Smith | SLE (most specific) | No |
| Anti-dsDNA | SLE | Yes, especially renal disease |
| Anti-histone | Drug-induced lupus | |
| Anti-U1-RNP | Mixed CTD | |
| Anti-Ro/SS-A | Sjögren syndrome, neonatal heart block, subacute SLE | |
| Anti-Ro/SS-A 60 kDa | ||
| Anti-Ro/SS-A 52 kDa | Systemic sclerosis and SLE, often with other antibodies present1 | |
| Anti-La/SSB | Sjögren syndrome, sicca syndrome, neonatal SLE | |
| Anti-Scl-70 | SSc and pulmonary fibrosis, dcSSc | |
| Anti-Jo-1 | Polymyositis, antisynthetase syndrome | |
| Anti-CCP | RA (most specific) | |
| Anti-smooth muscle | Autoimmune hepatitis | |
| Anti-PR3 (cANCA) | GPA | |
| Anti-MPO (pANCA) | MPA and eGPA | |
| Anti-parietal cell antibodies | Autoimmune gastritis and pernicious anemia; also Addison disease, autoimmune thyroiditis, type 1 diabetes mellitus, and primary ovarian failure |
References
- ^ B. Hervier, M. Rimbert, F. Colonna, M. A. Hamidou, M. Audrain. Clinical significance of anti-Ro/SSA-52 kDa antibodies--a retrospective monocentric study. Rheumatology. 2009;48(8):964-967. doi:10.1093/rheumatology/kep145.
