Corynebacterium jeikeium: Difference between revisions

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Corynebacterium jeikeium
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* Species of [[Corynebacterium|''Corynebacterium'']] that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
* Species of [[Corynebacterium|''Corynebacterium'']] that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
* Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
* Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
* Essentially universally susceptible to [[vancomycin]] and [[linezolid]]

* High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible<ref name=":0">Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV, Patel SN. ''In Vitro'' Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01776-17. doi: [https://doi.org/10.1128/aac.01776-17 10.1128/AAC.01776-17]. PMID: [https://pubmed.ncbi.nlm.nih.gov/29339389/ 29339389]; PMCID: [http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5914010/ PMC5914010].</ref>
{| class="wikitable sortable"
|+From <ref name=":0" />
!Antibiotic
!Isolates
!% Susceptible
|-
|[[Penicillin]]
|76
|0
|-
|[[Ampicillin]]
|76
|ND
|-
|[[Oxacillin]]
|76
|ND
|-
|[[Erythromycin]]
|76
|11.8
|-
|[[Clindamycin]]
|76
|2.6
|-
|[[Ciprofloxacin]]
|75
|35.5
|-
|[[Levofloxacin]]
|75
|ND
|-
|[[Moxifloxacin]]
|76
|35.5
|-
|'''[[Tetracycline]]'''
|'''76'''
|'''92.1'''
|-
|'''[[Vancomycin]]'''
|'''76'''
|'''100'''
|-
|[[Trimethoprim-sulfamethoxazole]]
|76
|18.4
|-
|[[Tigecycline]]
|76
|ND
|-
|'''[[Rifampin]]'''
|'''76'''
|'''97.4'''
|-
|'''[[Quinupristin-dalfopristin]]'''
|'''76'''
|'''89.5'''
|-
|'''[[Linezolid]]'''
|'''76'''
|'''100'''
|-
|'''[[Gentamicin]]'''
|'''76'''
|'''81.6'''
|-
|'''[[Daptomycin]]'''
|'''75'''
|'''89.5'''
|-
|[[Chloramphenicol]]
|75
|ND
|-
|[[Nitrofurantoin]]
|76
|ND
|}
{| class="wikitable"
|
|
|
|
|
|
|-
|Penicillin
|76
|0.5 to >8
|>8
|>8
|0
|-
|    Ampicillin
|76
|≤0.12 to >8
|>8
|>8
|ND
|-
|    Oxacillin
|76
|0.5 to >4
|>4
|>4
|ND
|-
|    Erythromycin
|76
|≤0.25 to >4
|>4
|>4
|11.8
|-
|    Clindamycin
|76
|≤0.5 to >2
|>2
|>2
|2.6
|-
|    Ciprofloxacin
|75
|≤1 to >2
|>2
|>2
|35.5
|-
|    Levofloxacin
|75
|≤0.25 to >4
|>4
|>4
|ND
|-
|    Moxifloxacin<sup>''b''</sup>
|76
|≤0.25 to >4
|4
|>4
|35.5
|-
|    Tetracycline
|76
|≤2 to >16
|≤2
|≤2
|92.1
|-
|    Vancomycin
|76
|≤0.25 to 2
|0.50
|1
|100
|-
|    Trimethoprim-sulfamethoxazole
|76
|≤0.5 to >4
|>4
|>4
|18.4
|-
|    Tigecycline
|76
|≤0.03 to >0.5
|0.12
|0.25
|ND
|-
|    Rifampin
|76
|≤0.5 to >4
|≤0.5
|≤0.5
|97.4
|-
|    Quinupristin-dalfopristin
|76
|≤0.5 to 4
|≤0.5
|2
|89.5
|-
|    Linezolid
|76
|≤1
|≤1
|≤1
|100
|-
|    Gentamicin
|76
|≤2 to >16
|≤2
|>16
|81.6
|-
|    Daptomycin
|75
|≤0.5 to >4
|≤0.5
|1
|89.5
|-
|    Chloramphenicol
|75
|≤2 to >16
|4
|16
|ND
|-
|    Nitrofurantoin
|76
|≤32 to >64
|>64
|>64
|ND
|}
{{DISPLAYTITLE:''Corynebacterium jeikeium''}}
{{DISPLAYTITLE:''Corynebacterium jeikeium''}}
[[Category:Gram-positive bacilli]]
[[Category:Gram-positive bacilli]]

Revision as of 14:37, 27 September 2023

  • Species of Corynebacterium that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
  • Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
  • Essentially universally susceptible to vancomycin and linezolid
  • High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible[1]
From [1]
Antibiotic Isolates % Susceptible
Penicillin 76 0
Ampicillin 76 ND
Oxacillin 76 ND
Erythromycin 76 11.8
Clindamycin 76 2.6
Ciprofloxacin 75 35.5
Levofloxacin 75 ND
Moxifloxacin 76 35.5
Tetracycline 76 92.1
Vancomycin 76 100
Trimethoprim-sulfamethoxazole 76 18.4
Tigecycline 76 ND
Rifampin 76 97.4
Quinupristin-dalfopristin 76 89.5
Linezolid 76 100
Gentamicin 76 81.6
Daptomycin 75 89.5
Chloramphenicol 75 ND
Nitrofurantoin 76 ND
Penicillin 76 0.5 to >8 >8 >8 0
    Ampicillin 76 ≤0.12 to >8 >8 >8 ND
    Oxacillin 76 0.5 to >4 >4 >4 ND
    Erythromycin 76 ≤0.25 to >4 >4 >4 11.8
    Clindamycin 76 ≤0.5 to >2 >2 >2 2.6
    Ciprofloxacin 75 ≤1 to >2 >2 >2 35.5
    Levofloxacin 75 ≤0.25 to >4 >4 >4 ND
    Moxifloxacinb 76 ≤0.25 to >4 4 >4 35.5
    Tetracycline 76 ≤2 to >16 ≤2 ≤2 92.1
    Vancomycin 76 ≤0.25 to 2 0.50 1 100
    Trimethoprim-sulfamethoxazole 76 ≤0.5 to >4 >4 >4 18.4
    Tigecycline 76 ≤0.03 to >0.5 0.12 0.25 ND
    Rifampin 76 ≤0.5 to >4 ≤0.5 ≤0.5 97.4
    Quinupristin-dalfopristin 76 ≤0.5 to 4 ≤0.5 2 89.5
    Linezolid 76 ≤1 ≤1 ≤1 100
    Gentamicin 76 ≤2 to >16 ≤2 >16 81.6
    Daptomycin 75 ≤0.5 to >4 ≤0.5 1 89.5
    Chloramphenicol 75 ≤2 to >16 4 16 ND
    Nitrofurantoin 76 ≤32 to >64 >64 >64 ND
  1. ↑ 1.0 1.1 Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV, Patel SN. In Vitro Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01776-17. doi: 10.1128/AAC.01776-17. PMID: 29339389; PMCID: PMC5914010.
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