Immunodeficiency: Difference between revisions

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== Background ==
* Usually organized into:
* Usually organized into:
** [[Primary immunodeficiency]]
** [[Primary immunodeficiency]]
** [[Acquired immunodeficiency|Acquired (secondary) immunodeficiency]]
** [[Acquired immunodeficiency|Acquired (secondary) immunodeficiency]]
*** Includes [[immunosuppressive therapy]]
*** Includes [[immunosuppressive therapy]]
==Clinical Manifestations==

{| class="wikitable"
!Immune Defect
!Typical Infections
!Typical Organisms
|-
|cell-mediated (T cells)
|persistent viral infections, opportunistic infections, disseminated infections
|[[Pneumocystis jirovecii]], [[Cryptococcus]], [[Herpesviridae]]
|-
|humoural (B cells)
|respiratory infections with [[Encapsulated bacteria|encapsulated organisms]], [[chronic diarrhea]], [[aseptic meningitis]]
|[[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Giardia lamblia]], [[Campylobacter]], [[Enterovirus|enteroviruses]]
|-
|phagocytic
|recurrent [[Abscess|abscesses]], [[gingivitis]], [[Aphthous ulcer|aphthous ulcers]]
|[[Staphylococcus aureus]], [[Burkholderia cepacia]], [[Serratia marcescens]], [[Aspergillus]], [[Nocardia]]
|-
|monocytic
|disseminated infections and multifocal [[osteomyelitis]]
|[[non-tuberculous mycobacteria]], [[Salmonella]], [[Histoplasma capsulatum]], [[Coccidioides immitis]]
|-
|[[Toll-like receptors|TLR]]
|recurrent [[meningitis]], [[bacteremia]], absence of fever
|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Staphylococcus aureus]], [[HSV]]
|-
|complement
|recurrent [[bacteremia]] and [[meningitis]]
|[[Neisseria]]
|-
|T cells and phagocytes
|[[eczema]], [[kyphoscoliosis]], pathologic fratures, pulmonary and cutaneous infections, [[mucocutaneous candidiasis]]
|[[Staphylococcus aureus]], [[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Candida albicans]]
|}
[[Category:Immunology]]
[[Category:Immunology]]
[[Category:Immunocompromised hosts]]
[[Category:Immunocompromised hosts]]

Latest revision as of 00:07, 16 February 2023

Background

Clinical Manifestations

Immune Defect Typical Infections Typical Organisms
cell-mediated (T cells) persistent viral infections, opportunistic infections, disseminated infections Pneumocystis jirovecii, Cryptococcus, Herpesviridae
humoural (B cells) respiratory infections with encapsulated organisms, chronic diarrhea, aseptic meningitis Haemophilus influenzae, Streptococcus pneumoniae, Giardia lamblia, Campylobacter, enteroviruses
phagocytic recurrent abscesses, gingivitis, aphthous ulcers Staphylococcus aureus, Burkholderia cepacia, Serratia marcescens, Aspergillus, Nocardia
monocytic disseminated infections and multifocal osteomyelitis non-tuberculous mycobacteria, Salmonella, Histoplasma capsulatum, Coccidioides immitis
TLR recurrent meningitis, bacteremia, absence of fever Streptococcus pneumoniae, Neisseria meningitidis, Staphylococcus aureus, HSV
complement recurrent bacteremia and meningitis Neisseria
T cells and phagocytes eczema, kyphoscoliosis, pathologic fratures, pulmonary and cutaneous infections, mucocutaneous candidiasis Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Candida albicans