Erythema multiforme: Difference between revisions

Latest revision as of 17:06, 2 November 2022

Now considered a separate entity from Stevens-Johnson syndrome
More common in young adults, but can develop at any age
Classified as either:
- Minor: localized eruption with mild or no mucosal involvement
- Major: skin and mucosal erosions of raised atypical target lesions

Asymptomatic, erythematous discrete macules and papules
Lesions may have target-like, iris, or bullseye appearance
Most common on hands, wrists, and ankles
Mucosal involvement of oral cavity is common
- Tongue, palate, buccal mucosa, and gingiva are all commonly involved

@@ Line 11: / Line 11: @@
 * Drugs
 ** Antimicrobials
-*** [[Penicillins]]
+*** '''[[Penicillins]]'''
+*** '''[[Sulfonamides]]'''
 *** [[Tetracyclines]]
-*** [[Sulfonamides]]
 *** [[Azithromycin]]
 *** [[Antiretrovirals]], particularly [[nevirapine]]
@@ Line 23: / Line 23: @@
 *** [[Lamotrigine]]
 ** Others
+*** '''[[NSAIDs]]'''
 *** [[Ethosuximide]]
 *** [[Cocaine]]
-*** [[NSAIDs]]
 *** [[Salicylates]]
 *** [[Barbiturates]]
 *** [[Allopurinol]]
 * Infections
-** [[Herpes simplex virus]], types 1 and 2
+** '''[[Herpes simplex virus]],''' types 1 and 2 (most common)
 ** [[Mycoplasma pneumoniae]]
+** Other viruses: [[parapoxvirus]], [[varicella zoster virus]], [[adenovirus]], [[EBV]], [[CMV]], [[viral hepatitis]], [[coxsackievirus]], [[parvovirus B19]], [[HIV]]
+** [[Chlamydia psittaci]]
+** [[Salmonella]]
 ** [[Histoplasmosis]]
 ** [[Tuberculosis]]
+** [[Dermatophytes]]
 == Clinical Manifestations ==
 * Asymptomatic, erythematous discrete macules and papules
-* Lesions may have target, iris, or bullseye appearance
+* Lesions may have target-like, iris, or bullseye appearance
 * Most common on hands, wrists, and ankles
 * Mucosal involvement of oral cavity is common