Intravenous immune globulin

Dosing

Indication	Dose and Duration
Fetal/neonatal alloimmune thrombocytopenia, maternal	up to 2 g/kg weekly starting at 12-16 weeks gestation if previous fetus with intracranial hemorrhage, of up to 1 g/kg weekly starting at 20-26 weeks gestation otherwise
Fetal/neonatal alloimmune thrombocytopenia, infant	1 g/kg and reassess
Hemolytic disease of the fetus and newborn	0.5 g/kg over 4 hours
Immune thrombocytopenia, adult, acute	1 g/kg as a single dose; repeat if platelets do not increase by at least 30
Immune thrombocytopenia, adult, chronic	1-2 g/kg, as directed by a hematologist
Immune thrombocytopenia, pediatric	0.8 to 1 mg/kg as a single dose; can be repeated if no response
Post-transfusion purpura	up to 2 g/kg divided over 2 to 5 consecutive days; repeat if necessary
Pemphigus vulgaris	2 g/kg divided over 2 to 5 days every 4 weeks, then every 6 weeks after 6 months of therapy
Juvenile idiopathic inflammatory myopathy	2 g/kg initial divided over 2 days as initial dose, followed by maintenance dose of up to 2 g/kg total
Kawasaki disease	2 g/kg for 1 day; can be repeated if no response
Idiopathic inflammatory myopathy, including dermatomyositis and polymyositis	up to 2 g/kg over 2 days monthly for 3 to 6 months, then continued at decreasing freuqncy over 2 years
Primary and secondary immunodeficiency, adult	0.4 to 0.6 g/kg every 3 to 4 weeks
Primary and secondary immunodeficiency, pediatric	0.3 to 0.6 g/kg every 3 to 4 weeks, targetting tough of 700 mg/dL
Hematopoietic stem cell transplant in primary immunodeficiency	0.4-0.6 g/kg every 3 to 4 weeks
Kidney transplant from living donor to whom the patient is sensitized	2 g/kg monthly for 4 months
Pre-transplant heart	up to 1 g/kg monthly until transplant
Peri-transplant heart, lung, kidney, or pancreas	1 g/kg in divided doses with a course of plasmapheresis
Post-transplant, acute	1 g/kg/dose, can be divided if also getting plasmaphereesis
Post-transplant, chronic	1 g/kg monthly
Streptococcal toxic shock syndrome	1 g/kg on day one follower by 0.5 mg/kg daily for 2 days, or 0.15 g/kg daily for 5 days
Staphylococcal toxic shock syndrome	1 g/kg on day one follower by 0.5 mg/kg daily for 2 days, or 0.15 g/kg daily for 5 days