Cystic fibrosis antibiotic dosing

Medication	Coverage	Dose
Aztreonam	Burkholderia cepacia, Pseudomonas aeruginosa	2 g IV q8h
Cefazolin	Staphylococcus aureus	2 g IV q8h
Cefipime	Burkholderia cepacia, Pseudomonas aeruginosa	2 g IV q8h
Ceftazidime	Achromobacter, Burkholderia cepacia, Pseudomonas aeruginosa	2-3 g IV q6-8h (max 12 g/day)
Ceftazidime-avibactam	Pseudomonas aeruginosa	2.5 g IV q8h
Chloramphenicol	Achromobacter, Burkholderia cepacia	12.5-25 mg/kg/dose IV q6h (max 1g/dose) with drug monitoring to target peak 10-20 mcg/mL and trough 5-10 mcg/mL
Ciprofloxacin	Achromobacter, Pseudomonas aeruginosa	400 mg IV q8h or 750 mg p.o. BID to TID
Cloxacillin	Staphylococcus aureus	1-2 g IV q6h
Colistin	Achromobacter, Pseudomonas aeruginosa	2.5-5 mg/kg/day divided q8-12h (max 5 mg/kg/day)
Meropenem	Achromobacter, Burkholderia cepacia, Pseudomonas aeruginosa	2 g IV q8h
Piperacillin/tazobactam	Achromobacter, Pseudomonas aeruginosa	4.5 g IV q4-6h
Tigecycline	Achromobacter, MRSA, NTM, Stenotrophomonas maltophilia	100 mg IV load, then 50 mg IV q12h
Tobramycin	Pseudomonas aeruginosa	10 mg/kg/dose IV q24h with drug monitoring to target peak 20-40 mg/L and trough <1 mg/L
Vancomycin	MRSA	15-20 mg/kg/dose IV q8-12h to target trough 15-20 mg/L; or 15-20 mg/kg IV load then 30-40 mg/kg/day (max 60 mg/kg/day) IV continuous infusion, target steady state level 20-25 mg/L

Source: CF Canada