Corynebacterium jeikeium: Difference between revisions
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Corynebacterium jeikeium
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* Species of [[Corynebacterium |
* Species of [[Genus::Corynebacterium]] that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients |
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* Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis |
* Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis |
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* Essentially universally susceptible to [[vancomycin]] and [[linezolid]] |
* Essentially universally susceptible to [[vancomycin]] and [[linezolid]] |
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* High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible[[CiteRef::nemuchwala2018in]] |
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* High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible<ref name=":0">Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV, Patel SN. ''In Vitro'' Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01776-17. doi: [https://doi.org/10.1128/aac.01776-17 10.1128/AAC.01776-17]. PMID: [https://pubmed.ncbi.nlm.nih.gov/29339389/ 29339389]; PMCID: [http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5914010/ PMC5914010].</ref> |
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{| class="wikitable sortable" |
{| class="wikitable sortable" |
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|+From |
|+From [[CiteRef::nemuchwala2018in]] |
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!Antibiotic |
!Antibiotic |
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!Isolates |
!Isolates |
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|[[Nitrofurantoin]] |
|[[Nitrofurantoin]] |
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|76 |
|76 |
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|ND |
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|} |
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{| class="wikitable" |
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| |
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| |
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| |
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| |
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| |
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| |
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|- |
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|Penicillin |
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|76 |
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|0.5 to >8 |
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|>8 |
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|>8 |
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|0 |
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|- |
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| Ampicillin |
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|76 |
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|≤0.12 to >8 |
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|>8 |
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|>8 |
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|ND |
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|- |
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| Oxacillin |
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|76 |
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|0.5 to >4 |
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|>4 |
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|>4 |
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|ND |
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|- |
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| Erythromycin |
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|76 |
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|≤0.25 to >4 |
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|>4 |
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|>4 |
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|11.8 |
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|- |
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| Clindamycin |
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|76 |
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|≤0.5 to >2 |
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|>2 |
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|>2 |
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|2.6 |
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|- |
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| Ciprofloxacin |
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|75 |
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|≤1 to >2 |
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|>2 |
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|>2 |
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|35.5 |
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|- |
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| Levofloxacin |
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|75 |
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|≤0.25 to >4 |
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|>4 |
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|>4 |
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|ND |
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|- |
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| Moxifloxacin<sup>''b''</sup> |
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|76 |
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|≤0.25 to >4 |
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|4 |
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|>4 |
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|35.5 |
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|- |
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| Tetracycline |
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|76 |
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|≤2 to >16 |
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|≤2 |
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|≤2 |
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|92.1 |
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|- |
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| Vancomycin |
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|76 |
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|≤0.25 to 2 |
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|0.50 |
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|1 |
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|100 |
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|- |
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| Trimethoprim-sulfamethoxazole |
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|76 |
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|≤0.5 to >4 |
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|>4 |
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|>4 |
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|18.4 |
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|- |
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| Tigecycline |
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|76 |
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|≤0.03 to >0.5 |
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|0.12 |
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|0.25 |
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|ND |
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|- |
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| Rifampin |
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|76 |
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|≤0.5 to >4 |
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|≤0.5 |
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|≤0.5 |
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|97.4 |
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|- |
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| Quinupristin-dalfopristin |
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|76 |
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|≤0.5 to 4 |
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|≤0.5 |
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|2 |
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|89.5 |
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|- |
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| Linezolid |
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|76 |
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|≤1 |
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|≤1 |
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|≤1 |
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|100 |
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|- |
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| Gentamicin |
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|76 |
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|≤2 to >16 |
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|≤2 |
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|>16 |
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|81.6 |
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|- |
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| Daptomycin |
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|75 |
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|≤0.5 to >4 |
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|≤0.5 |
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|1 |
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|89.5 |
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|- |
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| Chloramphenicol |
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|75 |
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|≤2 to >16 |
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|4 |
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|16 |
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|ND |
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|- |
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| Nitrofurantoin |
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|76 |
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|≤32 to >64 |
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|>64 |
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|>64 |
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|ND |
|ND |
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|} |
|} |
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Latest revision as of 17:44, 19 September 2024
- Species of Corynebacterium that causes opportunistic infections, most closely associated with hematologic stem cell transplant patients
- Clinical presentations include bacteremia, prosthetic valve endocarditis, meningitis, and peritonitis
- Essentially universally susceptible to vancomycin and linezolid
- High rates of resistance to beta lactams; may be fluoroquinolone or tetracycline susceptible1
| Antibiotic | Isolates | % Susceptible |
|---|---|---|
| Penicillin | 76 | 0 |
| Ampicillin | 76 | ND |
| Oxacillin | 76 | ND |
| Erythromycin | 76 | 11.8 |
| Clindamycin | 76 | 2.6 |
| Ciprofloxacin | 75 | 35.5 |
| Levofloxacin | 75 | ND |
| Moxifloxacin | 76 | 35.5 |
| Tetracycline | 76 | 92.1 |
| Vancomycin | 76 | 100 |
| Trimethoprim-sulfamethoxazole | 76 | 18.4 |
| Tigecycline | 76 | ND |
| Rifampin | 76 | 97.4 |
| Quinupristin-dalfopristin | 76 | 89.5 |
| Linezolid | 76 | 100 |
| Gentamicin | 76 | 81.6 |
| Daptomycin | 75 | 89.5 |
| Chloramphenicol | 75 | ND |
| Nitrofurantoin | 76 | ND |
