Thrombocytopenia

Differential Diagnosis

• Decreased production
  • Viral infection
  • Malignancy
• Destruction/Consumption
  • Immune-mediated thrombocytopenic purpura (ITP)
    • Hepatitis C, HIV, and Helicobacter pylori
  • Thrombotic microangiopathy
    • TTP/HUS, other TMAs
• Sequestration
  • Splenomegaly

Investigations

• Rule out secondary causes with HCV, HIV, and H. pylori serology