Isavuconazole: Difference between revisions

From IDWiki
No edit summary
(updated aspergillus to EUCAST 2020)
Line 14: Line 14:
! rowspan="2" |Species
! rowspan="2" |Species
! rowspan="2" |ECOFF (mg/L)
! rowspan="2" |ECOFF (mg/L)
! colspan="4" |Breakpoints (μg/mL)
! colspan="3" |Breakpoints (μg/mL)
! colspan="4" |Breakpoints (mm)
|-
|-
! S
! S
!I
!ATU
!SDD
!R
!S
! I
!SDD
!R
!R
|-
|-
|[[Candida albicans]]
|[[Candida albicans]]
|
|
|
|
|
|
|
|
|
Line 38: Line 27:
|-
|-
|[[Candida glabrata]]
|[[Candida glabrata]]
|
|
|
|
|
|
|
|
|
Line 49: Line 33:
|-
|-
|[[Candida krusei]]
|[[Candida krusei]]
|
|
|
|
|
|
|
|
|
Line 60: Line 39:
|-
|-
|[[Candida parapsilosis]]
|[[Candida parapsilosis]]
|
|
|
|
|
|
|
|
|
Line 71: Line 45:
|-
|-
|[[Candida tropicalis]]
|[[Candida tropicalis]]
|
|
|
|
|
|
|
|
|
Line 82: Line 51:
|-
|-
|[[Cryptococcus neoformans]]
|[[Cryptococcus neoformans]]
|
|
|
|
|
|
|
|
|
Line 93: Line 57:
|-
|-
|[[Cryptococcus gattii]]
|[[Cryptococcus gattii]]
|
|
|
|
|
|
|
|
|
Line 105: Line 64:
|[[Aspergillus flavus]]
|[[Aspergillus flavus]]
|2
|2
|≤1
|—
|2
| colspan="2" rowspan="5" |
|
|>2
| colspan="4" rowspan="5" |
|-
|-
|[[Aspergillus fumigatus]]
|[[Aspergillus fumigatus]]
|2
|2
|≤1
|≤1
|>1
|2
|>2
|-
|-
|[[Aspergillus nidulans]]
|[[Aspergillus nidulans]]
|0.25
|0.25
|≤0.25
|≤0.25
|—
|>0.25
|>0.25
|-
|-
|[[Aspergillus niger]]
|[[Aspergillus niger]]
|4
|4
|—
|—
|—
|—
|—
Line 128: Line 89:
|1
|1
|≤1
|≤1
|>1
|
|>2
|}
|}
==Dosing==
==Dosing==

Revision as of 13:08, 22 October 2024

Background

Mechanism of Action

  • Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway

Spectrum of Activity

Breakpoints

Species ECOFF (mg/L) Breakpoints (μg/mL)
S ATU R
Candida albicans
Candida glabrata
Candida krusei
Candida parapsilosis
Candida tropicalis
Cryptococcus neoformans
Cryptococcus gattii
Aspergillus flavus 2 ≤1 2 >2
Aspergillus fumigatus 2 ≤1 2 >2
Aspergillus nidulans 0.25 ≤0.25 >0.25
Aspergillus niger 4
Aspergillus terreus 1 ≤1 >2

Dosing

  • Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily

Renal Dosing

  • No adjustment needed

Hepatic Dosing

  • No adjustment needed

Safety

Adverse Drug Reactions

  • Nausea, vomiting, diarrhea
  • Elevated liver enzymes
    • Generally transient ALT elevation that does not require change in therapy
    • May also include severe cholestatic or hepatocellular enzyme rises within the first few months of therapy
    • See also LiverTox
  • Hypokalemia

Drug-Drug Interactions