Drug-induced thrombotic microangiopathy: Difference between revisions
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(Created page with "== Background == * A thrombotic microangiopathy caused by exposure to certain medications * May present with a TTP- or HUS-like syndrome * Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic * Associations that are probably true include: bevacizumab, cocaine, '''cyclosporine''', docetaxel, everolimus, gemcitabine, interferon α, interferon β, interferon polycarboxylate...") |
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* May present with a [[TTP]]- or [[HUS]]-like syndrome |
* May present with a [[TTP]]- or [[HUS]]-like syndrome |
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* Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic |
* Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic |
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* Associations that are probably true include: [[bevacizumab]], [[cocaine]], [[Cyclosporine|'''cyclosporine''']], [[docetaxel]], [[everolimus]], [[gemcitabine]], [[interferon α]], [[interferon β]], [[interferon polycarboxylate]], [[mitomycin]], [[muromonab-CD3]], [[oxaliplatin]], [[penicillin]], [[pentostatin]], [[quetiapine]], [[Quinine|'''quinine''']], [[sirolimus]], [[sulfisoxazole]], [[sunitinib]], [[Tacrolimus|'''tacrolimus''']], [[trielina]], and [[vincristine]] |
* Associations that are probably true include: [[bevacizumab]], [[cocaine]], [[Cyclosporine|'''cyclosporine''']], [[docetaxel]], [[everolimus]], [[gemcitabine]], [[interferon α]], [[interferon β]], [[interferon polycarboxylate]], [[mitomycin]], [[muromonab-CD3]], [[oxaliplatin]], [[penicillin]], [[pentostatin]], [[quetiapine]], [[Quinine|'''quinine''']], [[sirolimus]], [[sulfisoxazole]], [[sunitinib]], [[Tacrolimus|'''tacrolimus''']], [[trielina]], and [[vincristine]][[CiteRef::al-nouri2015dr]] |
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== Further Reading == |
== Further Reading == |
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Latest revision as of 17:39, 19 September 2024
Background
- A thrombotic microangiopathy caused by exposure to certain medications
- May present with a TTP- or HUS-like syndrome
- Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic
- Associations that are probably true include: bevacizumab, cocaine, cyclosporine, docetaxel, everolimus, gemcitabine, interferon α, interferon β, interferon polycarboxylate, mitomycin, muromonab-CD3, oxaliplatin, penicillin, pentostatin, quetiapine, quinine, sirolimus, sulfisoxazole, sunitinib, tacrolimus, trielina, and vincristine1
Further Reading
- Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood. 2015 Jan 22;125(4):616-8. doi: 10.1182/blood-2014-11-611335. PMID: 25414441; PMCID: PMC4304106.
References
- ^ Zayd L. Al-Nouri, Jessica A. Reese, Deirdra R. Terrell, Sara K. Vesely, James N. George. Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood. 2015;125(4):616-618. doi:10.1182/blood-2014-11-611335.
