Indefinite antimicrobial therapy: Difference between revisions
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[[Atovaquone]] 1500 mg p.o. daily |
[[Atovaquone]] 1500 mg p.o. daily |
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[[Pentamidine]] 300 mg inhaled every 3-4 weeks |
[[Pentamidine]] 300 mg inhaled every 3-4 weeks |
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[[Clindamycin]] 300 mg p.o. daily plus pyrimethamine 15 mg p.o. daily |
[[Clindamycin]] 300 mg p.o. daily plus pyrimethamine 15 mg p.o. daily |
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|[[Benzathine penicillin]] 1.2 g IM every 3-4 weeks |
|[[Benzathine penicillin]] 1.2 g IM every 3-4 weeks |
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[[Penicillin V]] 250 mg p.o. twice daily |
[[Penicillin V]] 250 mg p.o. twice daily |
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[[Sulphonamide]] 1 g p.o. daily |
[[Sulphonamide]] 1 g p.o. daily |
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[[Erythromycin]] 250 mg p.o. twice daily |
[[Erythromycin]] 250 mg p.o. twice daily |
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|[[TMP-SMX]] SS half tablet p.o. daily or thrice weekly |
|[[TMP-SMX]] SS half tablet p.o. daily or thrice weekly |
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[[Trimethoprim]] 100-300 mg p.o. daily |
[[Trimethoprim]] 100-300 mg p.o. daily |
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[[Ciprofloxacin]] 125 mg p.o. daily |
[[Ciprofloxacin]] 125 mg p.o. daily |
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[[Cefalexin]] 125-250 mg p.o. daily |
[[Cefalexin]] 125-250 mg p.o. daily |
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[[Nitrofurantoin]] 50-100 mg p.o. daily |
[[Nitrofurantoin]] 50-100 mg p.o. daily |
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[[Norfloxacin]] 200 mg p.o. daily |
[[Norfloxacin]] 200 mg p.o. daily |
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|[[Dicloxacillin]] 500 mg p.o. three to four times daily |
|[[Dicloxacillin]] 500 mg p.o. three to four times daily |
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[[Clindamycin]] 300 mg p.o. four times daily |
[[Clindamycin]] 300 mg p.o. four times daily |
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[[Amoxicillin/clavulanic acid]] 500 mg p.o. three times daily |
[[Amoxicillin/clavulanic acid]] 500 mg p.o. three times daily |
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|[[Minocycline]] or [[doxycycline]] 100 mg p.o. twice daily |
|[[Minocycline]] or [[doxycycline]] 100 mg p.o. twice daily |
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[[Fluoroquinolone]] +/- [[rifampin]] |
[[Fluoroquinolone]] +/- [[rifampin]] |
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[[Fusidic acid]] + [[rifampin]] |
[[Fusidic acid]] + [[rifampin]] |
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|[[Metronidazole]] 10-20 mg/kg/day |
|[[Metronidazole]] 10-20 mg/kg/day |
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[[Ciprofloxacin]] 500 mg p.o. twice daily plus metronidazole |
[[Ciprofloxacin]] 500 mg p.o. twice daily plus metronidazole |
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|[[Rifaximin]] |
|[[Rifaximin]][[Clarithromycin]] + [[rifabutin]] + [[clofazimine]] |
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[[Clarithromycin]] + [[rifabutin]] + [[clofazimine]] |
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[[Clofazimine]] |
[[Clofazimine]] |
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Latest revision as of 16:39, 13 September 2024
- Includes suppressive and prophylactic therapy, as well as use for treatment of non-infectious diseases (e.g. acne and reactive airways)
| Indication | Antimicrobial | Alternative |
|---|---|---|
| Prophylaxis | ||
| PJP prophylaxis following transplantation | TMP-SMX SS or DS daily or thrice weekly | Dapsone 50-100 mg p.o. daily
Atovaquone 1500 mg p.o. daily Pentamidine 300 mg inhaled every 3-4 weeks Clindamycin 300 mg p.o. daily plus pyrimethamine 15 mg p.o. daily |
| Post-splenectomy | Amoxicillin 250-500 mg p.o. daily | |
| Rheumatic fever | Benzathine penicillin 1.2 g IM every 3-4 weeks
Penicillin V 250 mg p.o. twice daily Sulphonamide 1 g p.o. daily Erythromycin 250 mg p.o. twice daily |
|
| Spontaneous bacterial peritonitis | Norfloxacin 400 mg p.o. daily | TMP-SMX DS p.o. daily
Ciprofloxacin 750 mg p.o. weekly |
| Urinary tract infection | TMP-SMX SS half tablet p.o. daily or thrice weekly
Trimethoprim 100-300 mg p.o. daily Ciprofloxacin 125 mg p.o. daily Cefalexin 125-250 mg p.o. daily Nitrofurantoin 50-100 mg p.o. daily Norfloxacin 200 mg p.o. daily |
|
| Suppressive Therapy | ||
| Prosthetic joint infection with MSSA | Cefalexin 500 mg p.o. three or four times daily
Cefadroxil 500 mg p.o. twice daily |
Dicloxacillin 500 mg p.o. three to four times daily
Clindamycin 300 mg p.o. four times daily Amoxicillin/clavulanic acid 500 mg p.o. three times daily |
| Prosthetic joint infection with MRSA | TMP-SMX DS 1 tab p.o. twice daily | Minocycline or doxycycline 100 mg p.o. twice daily
Fluoroquinolone +/- rifampin Fusidic acid + rifampin Cefalexin 500 mg p.o. three to four times daily |
| Prosthetic joint infection with beta-hemolytic streptococci and enterococci | Penicillin V 500 mg p.o. two to four times daily
Amoxicillin 500 mg p.o. three times daily |
|
| Prosthetic joint infection with Gram-negative bacilli | Ciprofloxacin 250-500 mg p.o. twice daily
TMP-SMX DS 1 tab p.o. twice daily |
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| Non-Antimicrobial Properties | ||
| Acne | Minocycline 100 mg p.o. daily | Doxycycline, lymecycline, azithromycin, clindamycin, trimethoprim |
| Cystic fibrosis | Azithromycin 250-500 mg p.o. daily | |
| Inflammatory bowel disease | Metronidazole 10-20 mg/kg/day
Ciprofloxacin 500 mg p.o. twice daily plus metronidazole |
RifaximinClarithromycin + rifabutin + clofazimine |
| Reactive airway disease | Azithromycin 250 mg p.o. daily
Azithromycin 500 mg p.o. thrice weekly |
Moxifloxacin 400 mg p.o. daily for 5 days followed by pulsed every 8 weeks |
Further Reading
- Life-long antimicrobial therapy: where is the evidence? J Antimicrob Chemother. 2018;73:2601-2612. doi: 10.1093/jac/dky174
