Anemia: Difference between revisions

Revision as of 20:13, 30 August 2023

Elevated reticulocytes (normal marrow response)
- Hemolytic anemia
  - Intrinsic RBC defect
    - Hemoglobinopathy
    - Enzymopathy: G6PD deficiency
    - Membrane-cytoskeletal defects
      - Hereditary spherocytosis
      - Hereditary elliptocytosis
    - Paroxysmal nocturnal hemoglobinuria
  - Extracorpuscular
    - Microangiopathic hemolytic anemia
    - Drugs and toxins: oxygen, nitrates, chlorates, methylene blue, dapsone, cisplatin, arsine, copper, lead
    - Infections: malaria, HUS, Clostridium perfringens
    - Autoimmune hemolytic anemia
      - Cold and warm AIHA
Low or inappropriately normal reticulocytes (poor marrow response or low erythropoietin)
- Chronic kidney disease

CBC with differential
- MCHC increased in HS and Hb SS
- MCH decreased in hypochromic anemias
- RDW increased in iron deficiency, reticulocytosis, blood transfusion
Reticulocyte count (normally 1-2%)
Peripheral blood film
Ferritin, transferrin saturation
Vitamin B12
SPEP, and UPEP or serum free light chains

@@ Line 5: / Line 5: @@
 * [[Iron-deficiency anemia]]
 * [[Thalassemia]]
-* [[Anemia of chronic inflammation]] (ferritin &lt; 100 and Fe Sat &lt; 20%)
+* [[Anemia of chronic inflammation]] (ferritin &lt; 100 and [[transferrin saturation]] &lt; 20%)
 * [[Lead poisoning]]
 * [[Sideroblastic anemia]]