Tumour necrosis factor-α inhibitors

From IDWiki
(Redirected from TNF-α inhibitors)


  • TNF-α is a cytokine involved in the inflammatory response to infection
  • Has soluble and transmembrane forms
  • Produced by macrophages, NK cells, granulocytes, fibroblasts, and T cells
  • Receptors for TNF-α (TNFR1 and TNFR2) are found on most human cells, and are involved in cell activation and proliferation, cytokine production, and granuloma formation



  • Active bacterial infection, active tuberculosis or untreated LTBI, active herpes zoster infection, active invasive fungal infection, infected skin ulcers, acute hepatitis B or C, untreated chronic hepatitis B, or chronic hepatitis B or C with Child-Pugh B or C


  • Baseline TST, ±CXR, prior to starting medications, with patients identified as having LTBI being offered prophylaxis
    • Cutoff for TST is 5 mm
  • Assess for hepatitis B prophylaxis

Adverse Effects