Background
- Non-treponemal diagnostic test for syphilis
- Used to trend titres in response to treatment
Interpretation
- Reported as the greatest dilution that is still positive
False positive
- Infectious
- Bacterial endocarditis, including rheumatic heart disease
- Chancroid
- Varicella-zoster virus
- Epstein-Barr virus
- Leprosy
- Lymphogranuloma venereum
- Malaria
- Mumps
- Mycoplasma pneumoniae
- Streptococcus pneumoniae
- Rickettsioses
- Tuberculosis
- Viral hepatitis
- Viral pneumonia
- Other treponemal infections such as yaws, pinta, or bejel
- Non-infectious
- Older age
- Chronic liver disease
- Connective tissue diseases such as rheumatoid arthritis
- Injection drug use
- Malignancy
- Multiple myeloma
- Pregnancy
- Ulcerative colitis
