Pleuritic chest pain

Differential Diagnosis

• Common: pulmonary embolism, myocardial infarction, pneumothorax, pericarditis, and pneumonia
• Cardiac: Dressler syndrome, post-pericardiotomy, post-cardiac injury
• Toxins: asbestosis
• Medications: amiodarone, cyclophosphamide, methotrexate, methysergide, minoxidil, mitomycin, oxyprenolol, practolol, procarbazine
• Gastrointestinal: IBD, spontaneous bacterial pleuritis
• Genetic: Familial Mediterranean fever
• Hematologic: malignancy, sickle cell disease
• Infectious:
  • Viral: adenovirus, coxsackievirus, CMV, EBV, influenza, mumps, parainfluenza, RSV
  • Bacterial: Mediterranean spotted fever, parapneumonic effusion, tuberculous pleuritis
  • Parasitic: amebiasis, paragonimiasis
• Inflammatory: reactive eosinophilic pleuritis
• Renal: CKD, renal capsular hematoma
• Rheumatologic:
  • Lupus pleuritis, including drug-induced lupus from hydralazine, procainamide, or quinidine
  • Rheumatoid pleuritis, Sjögren syndrome