Necrotizing soft tissue infection

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Eagle Effect

  • Originally, referred to decreased effectiveness of penicillins at high concentrations
  • Now, refers to decreased effectiveness of penicillins at high bacterial burden (when in stationary phase)
  • Clindamycin kills enough of the bacteria that are in stationary phase that the bacteria return to logarithmic growth phase, where penicillins are more effective

Further Reading

  1. Nicolás Cortés-Penfield, Jonathan H Ryder, Should Linezolid Replace Clindamycin as the Adjunctive Antimicrobial of Choice in Group A Streptococcal Necrotizing Soft Tissue Infection and Toxic Shock Syndrome? A Focused Debate, Clinical Infectious Diseases, 2022;, ciac720,