Intravenous immune globulin
From IDWiki
Dosing
| Indication | Dose and Duration |
|---|---|
| Fetal/neonatal alloimmune thrombocytopenia, maternal | up to 2 g/kg weekly starting at 12-16 weeks gestation if previous fetus with intracranial hemorrhage, of up to 1 g/kg weekly starting at 20-26 weeks gestation otherwise |
| Fetal/neonatal alloimmune thrombocytopenia, infant | 1 g/kg and reassess |
| Hemolytic disease of the fetus and newborn | 0.5 g/kg over 4 hours |
| Immune thrombocytopenia, adult, acute | 1 g/kg as a single dose; repeat if platelets do not increase by at least 30 |
| Immune thrombocytopenia, adult, chronic | 1-2 g/kg, as directed by a hematologist |
| Immune thrombocytopenia, pediatric | 0.8 to 1 mg/kg as a single dose; can be repeated if no response |
| Post-transfusion purpura | up to 2 g/kg divided over 2 to 5 consecutive days; repeat if necessary |
| Pemphigus vulgaris | 2 g/kg divided over 2 to 5 days every 4 weeks, then every 6 weeks after 6 months of therapy |
| Juvenile idiopathic inflammatory myopathy | 2 g/kg initial divided over 2 days as initial dose, followed by maintenance dose of up to 2 g/kg total |
| Kawasaki disease | 2 g/kg for 1 day; can be repeated if no response |
| Idiopathic inflammatory myopathy, including dermatomyositis and polymyositis | up to 2 g/kg over 2 days monthly for 3 to 6 months, then continued at decreasing freuqncy over 2 years |
| Primary and secondary immunodeficiency, adult | 0.4 to 0.6 g/kg every 3 to 4 weeks |
| Primary and secondary immunodeficiency, pediatric | 0.3 to 0.6 g/kg every 3 to 4 weeks, targetting tough of 700 mg/dL |
| Hematopoietic stem cell transplant in primary immunodeficiency | 0.4-0.6 g/kg every 3 to 4 weeks |
| Kidney transplant from living donor to whom the patient is sensitized | 2 g/kg monthly for 4 months |
| Pre-transplant heart | up to 1 g/kg monthly until transplant |
| Peri-transplant heart, lung, kidney, or pancreas | 1 g/kg in divided doses with a course of plasmapheresis |
| Post-transplant, acute | 1 g/kg/dose, can be divided if also getting plasmaphereesis |
| Post-transplant, chronic | 1 g/kg monthly |
| Streptococcal toxic shock syndrome | 1 g/kg on day one follower by 0.5 mg/kg daily for 2 days, or 0.15 g/kg daily for 5 days |
| Staphylococcal toxic shock syndrome | 1 g/kg on day one follower by 0.5 mg/kg daily for 2 days, or 0.15 g/kg daily for 5 days |
